Identification of the "thymic Treg niche" which maintains regulatory T cell maturation and analysis of its molecular mechanisms
| Project/Area Number |
24790488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
FUKAZAWA Taro 独立行政法人理化学研究所, バイオリソースセンター, 特別研究員 (10565774)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 制御性T細胞 / 胸腺 |
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| Research Abstract |
Regulatory T cells (Tregs) development occurs predominantly within the thymus, but the factors or signalings which are associated to Treg development and its egress from thymus remains unclear. To approach this matter, we utilize a "Treg niche" hypothesis; there are some micro environments for Treg differentiation and maturation in the thymus. In this study, we identified a new Treg maturation marker. And more, we suggest that there are some thymic stromal cells except thymic epithelial cells which play pivotal roles for mature Treg egress from the thymus.
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Report
(3 results)
Research Products
(4 results)
