Identification of the "thymic Treg niche" which maintains regulatory T cell maturation and analysis of its molecular mechanisms

Research Project

Project/Area Number	24790488
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Immunology
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	FUKAZAWA Taro 独立行政法人理化学研究所, バイオリソースセンター, 特別研究員 (10565774)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	制御性T細胞 / 胸腺
Research Abstract	Regulatory T cells (Tregs) development occurs predominantly within the thymus, but the factors or signalings which are associated to Treg development and its egress from thymus remains unclear. To approach this matter, we utilize a "Treg niche" hypothesis; there are some micro environments for Treg differentiation and maturation in the thymus. In this study, we identified a new Treg maturation marker. And more, we suggest that there are some thymic stromal cells except thymic epithelial cells which play pivotal roles for mature Treg egress from the thymus.

Report

(3 results)