Development of psoriasis-like chronic dermatitis in RhoH deficient mice
| Project/Area Number |
24790491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | 独立行政法人国立国際医療研究センター |
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Principal Investigator |
TAMEHIRO Norimasa 独立行政法人国立国際医療研究センター, その他部局等, その他 (80597881)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | T細胞 / 乾癬 |
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| Research Abstract |
RhoH, a hematopoietic lineage cell specific atypical small GTPase, plays the critical roles on T cell development and activation. As a specific target gene during thymocytes development, we have focused on RhoH and generated knock-out mice. These mice showed to the spontaneous development of psoriasis-like chronic dermatitis. The psoriatic eruption occurring in RhoH null mice might be dependent on the function of lymphocyte.
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Report
(3 results)
Research Products
(8 results)
