Development of psoriasis-like chronic dermatitis in RhoH deficient mice

• Project/Area Number: 24790491
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: 独立行政法人国立国際医療研究センター
• Principal Investigator: TAMEHIRO Norimasa 独立行政法人国立国際医療研究センター, その他部局等, その他 (80597881)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: T細胞 / 乾癬

Research Abstract

RhoH, a hematopoietic lineage cell specific atypical small GTPase, plays the critical roles on T cell development and activation. As a specific target gene during thymocytes development, we have focused on RhoH and generated knock-out mice. These mice showed to the spontaneous development of psoriasis-like chronic dermatitis. The psoriatic eruption occurring in RhoH null mice might be dependent on the function of lymphocyte.

Research Products

• [Journal Article] Differential Function of Themis CABIT Domains during T Cell Development. (2014)
  • Author(s): Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e89115-e89115
  • DOI: 10.1371/journal.pone.0089115
  • Peer Reviewed
• [Journal Article] Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells. (2013)
  • Author(s): Oda, H.
  • Journal Title: Immunol Lett. Volume: 151 Issue: 1-2 Pages: 1-9
  • DOI: 10.1016/j.imlet.2013.02.007
  • Peer Reviewed
• [Presentation] Post - translational regulation of RhoH via the proteasomal pathway (2014)
  • Author(s): Norimasa Tamehiro
  • Organizer: 99th Annual Meeting The American Association of Immunologists
  • Place of Presentation: Boston
  • Year and Date: 2014-05-06
• [Presentation] A non - synonymous SNP variant of RhoH reduces TCR mediated signal transduction via proteasomal degradation (2013)
  • Author(s): Norimasa Tamehiro
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 幕張
  • Year and Date: 2013-12-11
• [Presentation] A non-synonymous SNP variant of RhoH reduces TCR mediated signal transduction via proteasomal degradation (2013)
  • Author(s): Norimasa Tamehiro, Hiroyo Oda, Harumi Suzuki
  • Organizer: 日本免疫学会 総会
  • Place of Presentation: 幕張メッセ
• [Presentation] TCR-dependent proteasomal degradation of RhoH in CD4CD8 double positive thymocytes (2012)
  • Author(s): Norimasa Tamehiro
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] Post-translational regulation of RhoH via the proteasomal pathway (2012)
  • Author(s): Norimasa Tamehiro, Hiroyo Oda and Harumi Suzuki
  • Organizer: 99th Annual Meeting, The American Association of Immunologists
  • Place of Presentation: ボストン
• [Presentation] TCR-dependent proteasomal degradation of RhoH in CD4CD8 double positive thymocytes (2012)
  • Author(s): Norimasa Tamehiro, Hiroyo Oda, and Harumi Suzuki
  • Organizer: 日本免疫学会 総会
  • Place of Presentation: 神戸