| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
First, we synthesized [19F]-interleukin-8 (IL-8) which contained non-labelled fluoroproline instead of proline using the cell-free protein synthesis system. We confirmed that pure and abundant [19F]-IL-8 could be obtained. The binding affinity of [19F]IlL-8 to IL8 receptors was retained. Next, we synthesized [18F]IL-8 using [18F]proline. After ion-exchanged chromatography, we could obtained [18F]IL-8 which had 91% of radiochemical purity in a short time.
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