The role of a membrane-bound glutathione transferase in the oxidative stress-induced mitochondria dysfunction
Project/Area Number |
24790533
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
|
Research Institution | University of the Ryukyus |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | グルタチオントランスフェラーゼ / ミトコンドリア / 透過性遷移 / 酸化ストレス / グルタチオンとランスフェラーゼ / 肝障害 / ミトコンドリア透過性遷移 / 膜透過性遷移 |
Outline of Final Research Achievements |
In the present study, we aimed to confirm the role of mtMGST1 in the oxidative stress-induced mitochondrial permeability transition (MPT) pore opening. We found that the inner membrane mtMGST1 and MPT regulator proteins such as ANT and CypD are involved in the oxidant peroxynitrite (PON)-induced MPT pore opening, which is mediated by a disulfide bond, and that PON induces mitochondrial swelling accompanied by formation of high molecular weight proteins complex (MPC) of mtMGST1, ANT, and CypD via caldiolipin(CL), which is a phospholipid exclusively located in mitochondria.
|
Report
(6 results)
Research Products
(5 results)