| Project/Area Number |
24790535
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病性腎症 / バイオマーカー / Kim-1 / OLETFラット / 腎臓学 / アルブミン / 尿細管 / 医療薬学 / ２型糖尿病 / 腎臓 / 慢性腎臓病（CKD) / 尿中アルブミン / OLETF ラット / 尿細管障害 |
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| Research Abstract |
Using spontaneous type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, we examined temporal pattern of novel tubular markers in the urine for early diagnosis and evaluation of the severity of diabetic nephropathy. Urinary kidney injury molecule-1 (Kim-1) showed significant elevation before increase in albuminuria and N-acetyl-beta-D-glucosaminidase (NAG) in the OLETF rats with histopathologically proven renal tubular injury, compared with non-diabetic controls, Long-Evans Tokushima Otsuka (LETO) rats. In addition, urinary human KIM-1 showed elevation in type 2 diabetic patients with nephropathy compared with nondiabetic patients. Thus, urinary Kim-1 is a useful biomarker for the detection of early stage of type 2 diabetic nephropathy.
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