A rodent model of impaired gastric motility resulting from gastric low-grade inflammation induced by allyl isothiocyanate to evaluate therapeutic agents for functional dyspepsia
Project/Area Number |
24790536
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | Josai International University |
Principal Investigator |
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Research Collaborator |
RAIMURA Masaki
OKUMI Hirokuni
SON Yonshiru
TAKEUCHI Tetuya
TAKANO Shota
HASHIMOTO Kazuki
IMAI Taku
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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Keywords | アリルイソチオシアネート / カプサイシン / 機能性ディスペプシア / 胃粘膜微小炎症 / 実験動物 / ワサビ受容体TRPA1 / バニロイド受容体TRPV1 / 国際情報交換 / 胃運動 / 機能性ディスペプシア (FD) / 神経原性炎症 / ラット / マウス / 胃粘膜 |
Outline of Final Research Achievements |
The animal model of functional dyspepsia (FD) such as gastric motor dysfunction and chronic hypersensitivity has been reported, yet those models take a long time to be the onset of gastrointestinal dysfunction for the study of FD. We have shown the gastrointestinal pharmacological effects of allyl isothiocyanate (AITC), a pungent ingredient of wasabi and a TRPA1 channel activator. It was found that 1) AITC impairs tight junction barrier in primary cultures of rat stomachs (Capsaicin-sensitive neural afferentation and the gastrointestinal tract: from bench to bedside 2014, DOI: 10.5772/57289), and 2) no gastric damage by AITC was observed in ex-vivo rat stomachs (Gastroenterology, 138 (5), S-721, 2010). Therefore, this study is to establish a rodent model of impaired gastric motility resulting from gastric low-grade inflammation by AITC, which is reliable produce to evaluate therapeutic agents of FD.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.2014
Author(s)
Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
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Journal Title
J Pharmacol Exp Ther.
Volume: 348
Pages: 383-392
Related Report
Peer Reviewed / Open Access
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[Journal Article] Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice2012
Author(s)
Matsumoto, K., Lo, Wah, M., Hosoya, T., Tashima, K., Takayama, H., Murayama, T., Hone, S.
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Journal Title
Laboratory Investigation
Volume: 92
Issue: 5
Pages: 769-782
DOI
Related Report
Peer Reviewed
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