| Project/Area Number |
24790536
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Josai International University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
RAIMURA Masaki
OKUMI Hirokuni
SON Yonshiru
TAKEUCHI Tetuya
TAKANO Shota
HASHIMOTO Kazuki
IMAI Taku
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | アリルイソチオシアネート / カプサイシン / 機能性ディスペプシア / 胃粘膜微小炎症 / 実験動物 / ワサビ受容体TRPA1 / バニロイド受容体TRPV1 / 国際情報交換 / 胃運動 / 機能性ディスペプシア (FD) / 神経原性炎症 / ラット / マウス / 胃粘膜 |
|---|
| Outline of Final Research Achievements |
The animal model of functional dyspepsia (FD) such as gastric motor dysfunction and chronic hypersensitivity has been reported, yet those models take a long time to be the onset of gastrointestinal dysfunction for the study of FD. We have shown the gastrointestinal pharmacological effects of allyl isothiocyanate (AITC), a pungent ingredient of wasabi and a TRPA1 channel activator. It was found that 1) AITC impairs tight junction barrier in primary cultures of rat stomachs (Capsaicin-sensitive neural afferentation and the gastrointestinal tract: from bench to bedside 2014, DOI: 10.5772/57289), and 2) no gastric damage by AITC was observed in ex-vivo rat stomachs (Gastroenterology, 138 (5), S-721, 2010). Therefore, this study is to establish a rodent model of impaired gastric motility resulting from gastric low-grade inflammation by AITC, which is reliable produce to evaluate therapeutic agents of FD.
|
