Development of TSPO-PET imaging for noninvasive diagnosis of liver diseases
| Project/Area Number |
24790543
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | National Institute of Radiological Sciences |
|---|
Principal Investigator |
XIE Lin 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (30623558)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 肝疾患 / 脂肪肝 / TSPO / PET / [18]FEDAC / 画像診断法 / [18F]FEDAC / 生体分子 / 肝癌 |
|---|
| Outline of Final Research Achievements |
Due to the limitations of liver biopsy and currently available noninvasive imaging techniques, new noninvasive approaches for diagnosis of liver diseases, especially the most common subgroup fatty liver disease (FLD), have become an urgent requirement. In this study, we focused on the mitochondrial dysfunction that is responsible for disease progression of FLD, and translocator protein (18 kDa)(TSPO)-a mitochondrial transmembrane protein, explored whether TSPO can be used as an imaging biomarker of noninvasive diagnosis and staging of FLD, monitored using PET with a TSPO specific radioligand [18F]FEDAC. Our data demonstrated TSPO is a good imaging biomarker, and [18F]FEDAC-PET can accurate and noninvasive diagnosis and staging of FLD with excellent sensitivity and specificity. Our study may open a novel avenue for noninvasive and reliable clinic screening of FLD focusing on the general population.
|
Report
(4 results)
Research Products
(13 results)
-
[Journal Article] Visualization of acute liver damage induced by cycloheximide in rats using PET with [(18)F]FEDAC, a radiotracer for translocator protein (18 kDa).2014
Author(s)
Hatori A, Yui J, Xie L, Yamasaki T, Kumata K, Fujinaga M, Wakizaka H, Ogawa M, Nengaki N, Kawamura K, Zhang MR.
-
Journal Title
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Molecular imaging of ectopic metabotropic glutamate 1 receptor in melanoma with a positron emission tomography radioprobe 18 F-FITM2014
Author(s)
Xie L, Yui J, Fujinaga M, Hatori A, Yamasaki T, Kumata K, Wakizaka H, Furutsuka K, Takei M, Jin ZH, Furukawa T, Kawamura K, Zhang MR.
-
Journal Title
Int J Cancer.
Volume: 135
Pages: 1852-1859
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Translocator protein (18 kda), a potential molecular imaging biomarker for non-invasively distinguishing non-alcoholic fatty liver disease2012
Author(s)
Xie L, Yui J, Hatori A, Yamasaki T, Kumata K, Wakizaka H, Yoshida Y, Fujinaga M, Kawamura K, Zhang MR
-
Journal Title
Journal of hepatology
Volume: 57
Pages: 1076-1082
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
