The role of CREB gene polymorphisms in the individual differences in sensitivity to addictive substances and vulnerability to dependence
| Project/Area Number |
24790544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
NISHIZAWA Daisuke 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主任研究員 (80450584)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物依存 / 薬物感受性 / 薬物感受性・依存症脆弱性個人差の遺伝要因 / 遺伝子多型 / サイクリックAMP応答配列結合タンパク質 / 薬剤感受性 |
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| Outline of Final Research Achievements |
In association analyses for single nucleotide polymorphisms (SNPs) in and around the CREB3, CREB5, and ATF2 (CREB2) gene regions, only rs7583431 SNP flanking the ATF2 gene was significantly associated with the effect of opioid analgesic, fentanyl.
In additional association analyses, the C allele of the rs2952768 SNP, flanking the CREB1 gene, was associated with more analgesic requirements in patients who underwent abdominal surgery, just as observed in subjects who were scheduled to undergo cosmetic orthognathic surgery. Moreover, carriers of the C allele in this SNP exhibited less vulnerability to severe drug dependence in patients with methamphetamine dependence, alcohol dependence, and eating disorders and a lower “Reward Dependence” score on a personality questionnaire and higher Intelligence Quotient (IQ) score in two independent cohorts of healthy subjects. Furthermore, the C/C genotype of this SNP was significantly associated with the elevated mRNA expression of CREB1 gene.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Association Between <i>KCNJ6</i> (<i>GIRK2</i>) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence2014
Author(s)
Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K.
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 3
Pages: 253-263
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genome-wide association study identifies a potent locus associated with human opioid sensitivity.2014
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K.
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Journal Title
Mol Psychiatry
Volume: 19(1)
Issue: 1
Pages: 55-62
DOI
Related Report
Peer Reviewed
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[Presentation] ゲノムワイド関連解析によるオレキシン2受容体遺伝子多型Val308Ileとニコチン依存との関連の同定2014
Author(s)
西澤大輔, 笠井慎也, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
Organizer
平成26年度アルコール・薬物依存関連学会合同学術総会
Place of Presentation
パシフィコ横浜, 横浜
Year and Date
2014-10-03
Related Report
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[Presentation] PCLO SNP rs13438494 regulates DA and 5-HT uptake, accompanied with splicing efficiency and dependence-like behaviors in genomic association studies2014
Author(s)
Uno K, Nishizawa D, Seo S, Sasaki N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Ikeda K, Miyamoto Y, Nitta A
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-24
Related Report
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[Presentation] Associations of an orexin (hypocretin) receptor 2 gene polymorphism with nicotine dependence found in genome-wide and following association studies2014
Author(s)
Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Tanaka M, Sugimura H, Ikeda K
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-23
Related Report
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[Presentation] Personalized pain control2014
Author(s)
Ikeda K, Nishizawa D, Hayashida M, Fukuda K
Organizer
2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
Place of Presentation
Soul, Korea
Year and Date
2014-06-20
Related Report
Invited
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[Presentation] Genome-wide association study identifies a potent locus associated with human opioid sensitivity
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Nagashima M, Satoh Y, Higuchi S, Ujike H, Arinami T, Hayashida M, Ikeda K
Organizer
XXIst World Congress of Psychiatric Genetics
Place of Presentation
Boston, USA
Related Report
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[Presentation] Genome-wide association study identifies a potent locus associated with human opioid sensitivity
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K
Organizer
European Human Genetics Conference 2013
Place of Presentation
Paris, France
Related Report
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