The prospective study of effect of ifenprodil on relapse prevention in patients with substance dependence

• Project/Area Number: 24790545
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Yokohama City University (2013-2014); Tokyo Metropolitan Institute of Medical Science (2012)
• Principal Investigator: SUGAYA Nagisa 横浜市立大学, 医学部, 助教 (90508425)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: GIRKチャネル / アルコール依存症 / 飲酒行動 / 前向き研究 / 再飲酒リスク

Outline of Final Research Achievements

The present prospective randomized controlled study investigated the effect of G protein-activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol reuse in patients with alcohol dependence. The participants were 46 outpatients with alcohol dependence who were assigned to an ifenprodil group (administered 60 mg ifenprodil [Cerocral] per day for 3 months) and control group (administered 600 mg ascorbic acid and calcium pantothenate [Cinal] as a control drug per day for 3 months). The participants completed a questionnaire that included the frequency of alcohol drinking and presence of heavy drinking before the study period (time 1) and 3 months after the start of the study period (time 2). The alcohol reuse total score was calculated using these two items. Analysis of covariance showed that the alcohol reuse total score at time 2 in the ifenprodil group was significantly lower than in the control group after adjusting the score at time 1.

Research Products

• [Journal Article] 過敏性腸症候群における脳腸相関（特集 身体と精神のクロストーク） (2014)
  • Author(s): 菅谷 渚
  • Journal Title: 精神科 Volume: 24 Pages: 288-294
  • NAID: 40020023134
• [Journal Article] Role of GIRK channels in addictive substance effects. (2013)
  • Author(s): Sugaya N, Kobayashi T, Ikeda K
  • Journal Title: J Drug Alcohol Res Volume: 2 Pages: 1-11
  • DOI: 10.4303/jdar/235823
  • Peer Reviewed
• [Journal Article] Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients. (2013)
  • Author(s): Sugaya N, Yoshida E, Yasuda S, Tochigi M, Takei K, Ohtani T, Otowa T, Minato T, Umekage T, Sakano Y, Chen J, Shimada H, Nomura S, Okazaki Y, Kaiya H, Tanii H, Sasaki T
  • Journal Title: Psychiatry Clin Neurosci Volume: 67(6) Issue: 6 Pages: 397-404
  • DOI: 10.1111/pcn.12069
  • Peer Reviewed
• [Journal Article] Prevalence of bipolar disorder in panic disorder patients in the Japanese population. (2013)
  • Author(s): Sugaya N,Otowa T 7/18, Umekage T 9/18, Sasaki T17/18
  • Journal Title: J Affect Disord. Volume: 147(1-3) Issue: 1-3 Pages: 411-5
  • DOI: 10.1016/j.jad.2012.10.014
  • Peer Reviewed
• [Journal Article] General Workers Living with Younger Children in Fukushima Performed more Preventive Behavior against Radiation during and after the Nuclear Disaster (2013)
  • Author(s): Kanda H, Sugaya N, Takahashi K, Mizushima S, Koyama K
  • Journal Title: Asian Pacific journal of cancer prevention Volume: 14 Issue: 11 Pages: 6893-6897
  • DOI: 10.7314/apjcp.2013.14.11.6893
  • Peer Reviewed
• [Journal Article] The biological effects of acute psychosocial stress on delay discounting (2013)
  • Author(s): Kimura K, Izawa S, Sugaya N, Ogawa N, Yamada KC, Shirotsuki K, Mikami I, Hirata K, Nagano Y, Hasegawa T
  • Journal Title: Psychoneuroendocrinology Volume: 38 Issue: 10 Pages: 2300-2308
  • DOI: 10.1016/j.psyneuen.2013.04.019
  • Peer Reviewed
• [Journal Article] An increase in salivary interleukin-6 level following acute psychosocial stress and its biological correlates in healthy young adults (2013)
  • Author(s): Izawa S, Sugaya N, Kimura K, Ogawa N, Yamada KC, Shirotsuki K, Mikami I, Hirata K, Nagano Y, Nomura S
  • Journal Title: Biological psychology Volume: 94 Issue: 2 Pages: 249-254
  • DOI: 10.1016/j.biopsycho.2013.06.006
  • Peer Reviewed
• [Journal Article] Internet usage and knowledge of radiation health effects and preventive behaviours among workers in Fukushima after the Fukushima Daiichi nuclear power plant accident (2013)
  • Author(s): Kanda H, Takahashi K, Sugaya N, Mizushima S, Koyama K
  • Journal Title: Emergency medicine journal Volume: online Issue: e1 Pages: 1-6
  • DOI: 10.1136/emermed-2013-202955
  • Peer Reviewed
• [Journal Article] Influence of GIRK channel inhibition on relapse risk in Japanese alcohol-dependent inpatients (2012)
  • Author(s): Sugaya N, Ogai Y, Kakibuchi Y, Senoo E, Ikeda K
  • Journal Title: Japanese journal of psychopharmacology Volume: 32 Pages: 165-167
  • NAID: 10030807363
  • Peer Reviewed
• [Journal Article] Relationship Between Cognitive Factors and Anxiety in Individuals with Irritable Bowel Syndrome (2012)
  • Author(s): Sugaya N, Nomura S, Shimada H
  • Journal Title: International Journal of Behavioral Medicine Volume: 19 Issue: 3 Pages: 308-315
  • DOI: 10.1007/s12529-011-9195-0
  • Peer Reviewed
• [Presentation] A randomized and rater-blinded study of the effect of ifenprodil on alcohol reuse in patients with alcohol dependence (2014)
  • Author(s): Sugaya, N., Ogai, Y., Aikawa, Y., Yumoto, Y., Takahama, M., Tanaka, M., Haraguchi, A., Umeno, M., Ikeda, K.
  • Organizer: 16th International Society of Addiction Medicine Annual Meeting
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県）
  • Year and Date: 2014-10-02 – 2014-10-06
• [Presentation] 福島県内の一般労働者における原子力災害時の主観的な情報不足とその関連要因 (2014)
  • Author(s): 神田秀幸、菅谷 渚、高橋謙造、水嶋春朔、小山菊雄
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 艮陵会館・日立システムズホール仙台（宮城県仙台市）
• [Presentation] Anger tendency may be associated with duration of illness in panic disorder (2014)
  • Author(s): Sugaya N, Yohida E, Konishi Y, Okazaki Y, Kaiya H, Tanii H, Sasaki T
  • Organizer: 第6回日本不安障害学会学術大会
  • Place of Presentation: 東京大学（東京都文京区）
• [Presentation] 遺伝子研究における心理的評価（シンポジウム「不安障害の遺伝と疫学―多因子疾患へのアプローチ」） (2014)
  • Author(s): 菅谷 渚
  • Organizer: 第6回日本不安障害学会学術大会
  • Place of Presentation: 東京大学（東京都文京区）
• [Presentation] Salivary MHPG increase after awakening and its relationship with autonomic nervous activity and cortisol (2013)
  • Author(s): Sugaya N, Izawa S, Yamamoto R, Ogawa N, Yajima J, Okamura H, Horiuchi S, Tsuda A, Nomura S
  • Organizer: 43rd International Society of Psychoneuroendocrinology Conference
  • Place of Presentation: Leiden, Germany
• [Presentation] A randomized, rater blinded, crossover study of ifenprodil effect on relapse risk in patients with alcohol dependence (2013)
  • Author(s): Sugaya N, Ogai Y, Aikawa Y, Yumoto Y, Takahama M, Tanaka M, Haraguchi A, Umeno M, Ikeda K
  • Organizer: CINP Special Congress on Addiction
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Influence of GIRK channel inhibition on relapse risk in Japanese alcohol-dependent inpatients (2012)
  • Author(s): Sugaya N, Ogai Y, Kakibuchi Y, Senoo E, Ikeda K
  • Organizer: The International College of Neuro-Psychopharmacology 28th Congress
  • Place of Presentation: Stockholm
• [Presentation] Effect of GIRK channel inhibition on relapse risk in Japanese alcoholics (2012)
  • Author(s): Sugaya N, Ogai Y, Kakibuchi Y, Senoo E, Ikeda K
  • Organizer: 16th Congress of International Society for Biomedical Research on Alcoholism
  • Place of Presentation: 北海道
• [Presentation] Enhanced increase in cortisol/DHEA ratio under prolonged stress in individuals with irritable bowel syndrome (2012)
  • Author(s): Sugaya N, Izawa S, Saito K, Shirotsuki K, Nomura S, Shimada H, Ikeda K
  • Organizer: 42nd International Society of Psychoneuroendocrinology Conference
  • Place of Presentation: NewYork
• [Presentation] GIRK channel inhibitors decreased methamphetamine preference in mice and relapse risk scores in alcoholic (2012)
  • Author(s): Sugaya N, Ogai Y, Aikawa Y, Umeno M, Yumoto Y, Takahama M, Tanaka M, Kakibuchi Y, Senoo E, Takamatsu Y, Yamamoto H, Hagino Y, Markou A, Ikeda K
  • Organizer: American College of Neuropsychopharmacology, 51st Annual Meeting
  • Place of Presentation: Florida
• [Book] 青年期発達百科事典 第３巻 精神病理と非定型プロセス「タバコ使用」 (2014)
  • Author(s): 青年期発達百科事典 B. Bradford Brown, Mitchell J. Prinstein 編／子安増生・二宮克美 監訳／青年期発達百科辞典編集委員会 編／菅谷渚・池田和隆 訳（分担）
  • Total Pages: 1568
  • Publisher: 丸善出版
• [Remarks] Read & Researchmap
  • URL: http://researchmap.jp/nagisa_sugaya/