The prospective study of effect of ifenprodil on relapse prevention in patients with substance dependence
| Project/Area Number |
24790545
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Yokohama City University (2013-2014)
Tokyo Metropolitan Institute of Medical Science (2012) |
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Principal Investigator |
SUGAYA Nagisa 横浜市立大学, 医学部, 助教 (90508425)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | GIRKチャネル / アルコール依存症 / 飲酒行動 / 前向き研究 / 再飲酒リスク |
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| Outline of Final Research Achievements |
The present prospective randomized controlled study investigated the effect of G protein-activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol reuse in patients with alcohol dependence. The participants were 46 outpatients with alcohol dependence who were assigned to an ifenprodil group (administered 60 mg ifenprodil [Cerocral] per day for 3 months) and control group (administered 600 mg ascorbic acid and calcium pantothenate [Cinal] as a control drug per day for 3 months). The participants completed a questionnaire that included the frequency of alcohol drinking and presence of heavy drinking before the study period (time 1) and 3 months after the start of the study period (time 2). The alcohol reuse total score was calculated using these two items. Analysis of covariance showed that the alcohol reuse total score at time 2 in the ifenprodil group was significantly lower than in the control group after adjusting the score at time 1.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients.2013
Author(s)
Sugaya N, Yoshida E, Yasuda S, Tochigi M, Takei K, Ohtani T, Otowa T, Minato T, Umekage T, Sakano Y, Chen J, Shimada H, Nomura S, Okazaki Y, Kaiya H, Tanii H, Sasaki T
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Journal Title
Psychiatry Clin Neurosci
Volume: 67(6)
Issue: 6
Pages: 397-404
DOI
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Peer Reviewed
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[Presentation] A randomized and rater-blinded study of the effect of ifenprodil on alcohol reuse in patients with alcohol dependence2014
Author(s)
Sugaya, N., Ogai, Y., Aikawa, Y., Yumoto, Y., Takahama, M., Tanaka, M., Haraguchi, A., Umeno, M., Ikeda, K.
Organizer
16th International Society of Addiction Medicine Annual Meeting
Place of Presentation
パシフィコ横浜会議センター（神奈川県）
Year and Date
2014-10-02 – 2014-10-06
Related Report
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[Presentation] A randomized, rater blinded, crossover study of ifenprodil effect on relapse risk in patients with alcohol dependence2013
Author(s)
Sugaya N, Ogai Y, Aikawa Y, Yumoto Y, Takahama M, Tanaka M, Haraguchi A, Umeno M, Ikeda K
Organizer
CINP Special Congress on Addiction
Place of Presentation
Kuala Lumpur, Malaysia
Related Report
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[Presentation] GIRK channel inhibitors decreased methamphetamine preference in mice and relapse risk scores in alcoholic2012
Author(s)
Sugaya N, Ogai Y, Aikawa Y, Umeno M, Yumoto Y, Takahama M, Tanaka M, Kakibuchi Y, Senoo E, Takamatsu Y, Yamamoto H, Hagino Y, Markou A, Ikeda K
Organizer
American College of Neuropsychopharmacology, 51st Annual Meeting
Place of Presentation
Florida
Related Report
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