Antimicrobial Susceptibility and Molecular Epidemiology of Drug Resistance in S. maltophilia

• Project/Area Number: 24790546
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Tohoku University
• Principal Investigator: KANAMORI HAJIME 東北大学, 大学病院, 助教 (70625318)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 感染症 / S. maltophilia / 薬剤感受性 / Smqnr

Research Abstract

Stenotrophomonas maltophilia infections are difficult to treat as the bacterium exhibits high-level intrinsic resistance to a variety of antimicrobial agents. Smqnr have been recently identified in S. maltophilia as a novel chromosomal quinolone resistance gene. In this study, we investigated the antimicrobial susceptibility and the prevalence of Smqnr among S. maltophilia isolates in Japan. Resistance rates to ceftazidime, levofloxacin, trimethoprim-sulfamethoxazole, and minocycline were 67%, 6%, 18%, and 0%, respectively. Smqnr was detected at high frequencies in S. maltophilia isolates (approximately 60%), and there were regional differences in Smqnr frequency. In this study, we described novel variants of Smqnr.

Research Products

• [Journal Article] Tuberculosis Exposure among Evacuees at a Shelter after Earthquake, Japan, 2011 (2013)
  • Author(s): Kanamori H, Aso N, Tadano S, Saito M, Saito H, Uchiyama B, Ishibashi N, Inomata S, Endo S, Aoyagi T, Hatta M, Yamada M, Gu Y, Tokuda K, Yano H, Kunishima H, Hirakata Y, Saijyo T, Kitagawa M, Kaku M
  • Journal Title: Emerg Infect Dis Volume: 19 Issue: 5 Pages: 799-801
  • DOI: 10.3201/eid1905.121137
  • Peer Reviewed
• [Journal Article] Molecular characteristics of extended-spectrum β-lactamases in clinical isolates from Escherichia coli at a Japanese tertiary hospital (2013)
  • Author(s): Yano H, Uemura M, Endo S, Kanamori H, Inomata S, Kakuta R, Ichimura S, Ogawa M, Shimojima M, Ishibashi N, Aoyagi T, Hatta M, Gu Y, Yamada M, Tokuda K, Kunishima H, Kitagawa M, Hirakata Y, and Kaku M
  • Journal Title: PLoS One Volume: 8 Issue: 5 Pages: 64359-64359
  • DOI: 10.1371/journal.pone.0064359
  • Peer Reviewed
• [Journal Article] Lessons learned from a tuberculosis contact investigation associated with a disaster volunteer after the 2011 Great East Japan Earthquake (2013)
  • Author(s): Kanamori H, Uchiyama B, Hirakata Y, Chiba T, Okuda M, Kaku M
  • Journal Title: Am J Respir Crit Care Med Volume: 187 Issue: 11 Pages: 1278-1279
  • DOI: 10.1164/rccm.201212-2150le
  • Peer Reviewed
• [Journal Article] Molecular characteristics of extended-spectrumβ-lactamases and qnr determinants in Enterobacter species from Japan (2012)
  • Author(s): Kanamori H, Yano H, Hirakata Y, Hirotani A, Arai K, Endo S, Ichimura S, Ogawa M, Shimojima M, Aoyagi T, Hatta M, Yamada M, Gu Y, Tokuda K, Kunishima H, Kitagawa M, Kaku M
  • Journal Title: PLoS One Volume: 7 Issue: 6 Pages: 37967-37967
  • DOI: 10.1371/journal.pone.0037967
  • Peer Reviewed
• [Journal Article] High frequency of IMP-6 among clinical isolates of metallo-β-lactamase-producing Escherichia coli in Japan (2012)
  • Author(s): Yano H, Ogawa M, Endo S, Kakuta R, Kanamori H, Inomata S, Ishibashi N, Aoyagi T, Hatta M, Gu Y, Yamada M, Tokuda K, Kunishima H, Kitagawa M, Hirakata Y, Kaku M
  • Journal Title: Antimicrob Agents Chemother Volume: 56 Issue: 8 Pages: 4554-4555
  • DOI: 10.1128/aac.00617-12
  • Peer Reviewed
• [Journal Article] Descriptive analysis of healthcare-associated infections other than bloodstream, respiratory, urinary tract, or surgical site infections (2012)
  • Author(s): Kanamori H, Weber DJ, Sickbert-Bennett EE, Brown V, Kaku M, Rutala WA
  • Journal Title: Infect Control Hosp Epidemiol Volume: 33 Issue: 12 Pages: 1276-1278
  • DOI: 10.1086/668423
  • Peer Reviewed
• [Presentation] 本邦におけるStenotrophomonas maltophiliaのSmqnrに関する検討 (2014)
  • Author(s): 金森肇、田内絢子、矢野寿一、遠藤史郎、小川美保、霜島正浩、賀来満夫
  • Organizer: 第25回日本臨床微生物学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-02-01
• [Presentation] Role of Clinical Laboratory Test and Lessons Learned from Infection Control and Prevention in the Affected Area (2013)
  • Author(s): Kanamori H, Nagasawa M, Endo S, Aoyagi T, Hatta M, Gu Y, Tokuda K, Yano H, Kaku M
  • Organizer: The 7th Asian Conference on Emergency Medicine
  • Place of Presentation: Tokyo
  • Year and Date: 2013-10-25
• [Presentation] Clinical Characteristics of Active Pulmonary Tuberculosis after the 2011 Great East Japan Earthquake (2013)
  • Author(s): Kanamori H, Aso N, Uchiyama B, Saito H, Hirakata Y, Kaku M
  • Organizer: IDWeek2013
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2013-10-05
• [Presentation] Application of phage open-reading frame typing to methicillin-resistant Staphylococcus aureus outbreak investigations in a Japanese tertiary care hospital (2012)
  • Author(s): Kanamori H, Tokuda K, Inomata S, Saito M, Ikeda S, Yano H, Kunishima H, Kitagawa M, and Kaku M
  • Organizer: 8th International Healthcare Infection Society (HIS) Conference and Federation of Infection Societies (FIS) annual conference
  • Place of Presentation: Liverpool, UK
  • Year and Date: 2012-11-19
• [Presentation] Clinical Characteristics of Active Pulmonary Tuberculosis after the 2011 Great East Japan Earthquake
  • Author(s): Kanamori H, Aso N, Uchiyama B, Saito H, Hirakata Y, Kaku M
  • Organizer: IDWeek2013
  • Place of Presentation: サンフランシスコ、米国
• [Presentation] Role of Clinical Laboratory Test and Lessons Learned from Infection Control and Prevention in the Affected Area
  • Author(s): Kanamori H, Nagasawa M, Endo S, Aoyagi T, Hatta M, Gu Y, Tokuda K, Yano H, Kaku M
  • Organizer: The 7th Asian Conference on Emergency Medicine
  • Place of Presentation: 東京