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The challenge to underlying causes of steroid insensitivity in bronchial asthma and its clinical application

Research Project

Project/Area Number 24790547
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionKansai Medical University (2013)
Akita University (2012)

Principal Investigator

KOBAYASHI Yoshiki  関西医科大学, 医学部, 助教 (10375298)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsステロイド抵抗性 / ホスファターゼ / 気管支喘息 / ステロイド受容体 / ストロイド受容体
Research Abstract

We examined the involvement of protein phosphatases as underlying causes of steroid insensitivity in severe asthma. We focused on phosphatases other than the phosphatase recently reported by us, and revealed that their protein expression levels were reduced in the cells obtained from severe asthmatics. We have optimized the detection methods of them in each cell by using imaging flow cytometer. In addition, the association between their expression levels and practical steroid insensitivity is under study, which might lead to a clinical application in future.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2013

All Presentation (6 results)

  • [Presentation] 炎症局所におけるステロイド抵抗性と接着能亢進のメカニズム検討2013

    • Author(s)
      小林良樹
    • Organizer
      第63回日本アレルギー学会秋季学術大会
    • Place of Presentation
      ホテルニューオータニ(東京都千代田区)
    • Related Report
      2013 Final Research Report
  • [Presentation] Impaired protein tyrosine phosphatase PTPRR reduces response to corticosteroid in mononuclear cells2013

    • Author(s)
      Yoshiki Kobayashi
    • Organizer
      The 23^<rd> Annual Congress of European Respiratory Society
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] 酸化ストレス下のステロイド感受性制御におけるPP2Aの役割2013

    • Author(s)
      小林良樹
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Final Research Report
  • [Presentation] Impaired protein tyrosine phosphatase PTPRR reduces rresponse to corticosteroid in mononuclear cells2013

    • Author(s)
      Yoshiki Kobayashi, Anna Miller-Larsson, Ito Kazuhiro, et al
    • Organizer
      The 23rd Annual Congress of European Respiratory Society
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸化ストレス下のステロイド感受性制御におけるPP2Aの役割2013

    • Author(s)
      小林良樹, Peter J. Barnes, Kazuhiro Ito
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 炎症局所におけるステロイド抵抗性と接着能亢進のメカニズム検討2013

    • Author(s)
      小林良樹, 今野泰典, 神田晃 他
    • Organizer
      第63回日本アレルギー学会秋季学術大会
    • Place of Presentation
      ホテルニューオータニ(東京都千代田区)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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