Effect of coagulation-regulation system by heme-oxygenase 1 on improvement of pregnancy outcome.
| Project/Area Number |
24790549
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
SEKIYA Akiko 金沢大学, 保健学系, 助教 (10452111)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 不育症 / 妊娠 / 血栓 / ヘムオキシゲナーゼ-1 / スタチン / 血液凝固・線溶 |
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| Outline of Final Research Achievements |
The pathogenesis of recurrent miscarriage is poorly understood.
The blood coagulation-associated laboratory data of normal pregnant women demonstrated increased levels of thrombotic markers such as prothrombin fragment 1+2, thrombin-antithrombin complex, soluble fibrin and d-dimer. In BeWo cells, an in vitro model of the human placenta, TNF-α treatment enhanced expression of procoagulant proteins including tissue factor and plasminogen activator inhibitor-1 (PAI-1). Meanwhile, fluvastatin enhanced expression of anticoagulant proteins including tissue factor pathway inhibitor (TFPI) and a disintegrin and metalloproteinase with thrombospondin type 1 repeats (ADAMTS13) in human umbilical vein endothelial cells.
Those results indicate that pregnant women are at higher risk of thrombosis, which is accelerated by inflammation in some cases of adverse pregnancy outcome. Fluvastatin may improve antithrombotic properties of endothelium and attenuate thrombotic tendencies during pregnancy.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Antithrombin deficiency in three Japanese families: one novel and two reported point mutations in the antithrombin gene.2013
Author(s)
Maruyama K, Morishita E, Karato M, Kadono T, Sekiya A, Goto Y, Sato T, Nomoto H, Omi W, Tsuzura S, Imai H, Asakura H, Ohtake S, Nakao S.
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Journal Title
Thromb Res
Volume: 132
Issue: 2
Pages: e118-e123
DOI
Related Report
Peer Reviewed
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