Comprehensive study for detection of coronary endothelial dysfunction using microRNA array analysis
| Project/Area Number |
24790559
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagoya City University |
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Principal Investigator |
Sugiura Tomonori 名古屋市立大学, 医学(系)研究科(研究院), 助教 (60535235)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 動脈硬化 / マイクロRNA / 血管内皮 / 酸化ストレス / 高血圧 / 喫煙 / 脂質異常 / 冠動脈 / 狭心症 / 内皮障害 / microRNA / セロトニン / micorRNA / 冠動脈疾患 / 探索的研究 |
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| Outline of Final Research Achievements |
Vascular endothelial damage was improved and plasma levels of circulating microRNA-126 were increased after 8 weeks of smoking cessation, demonstrating variable circulating levels of microRNA in different conditions. The ratio of plasma/whole blood serotonin concentration showed significant association with oxidative stress in individuals with cardiovascular risks, and is a significant determinant of the incidence of coronary artery disease. Targeting serotonin-oxidative stress axis as a part of a holistic anti-atherothrombotic strategy is potentially benefitial in patients with atherosclerosis. Moreover, damages in the coronary endothelium affect circulating levels of endothelium-derived microRNAs. Further examination is necessary to establish the clinical significance of microRNAs.
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Report
(5 results)
Research Products
(4 results)
