| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
IL-18 promotes the production of IFN and granulocyte-macrophage CSF and inhibits IL-10 production. In humans, IL-18 concentrations are reported to be increased in individuals with type 2 diabetes and in obese individuals. However, detailed functions of IL-18 in diabetes are still unclear.
The purpose of this study was to investigate the effects of oxidative modification on the IL-18 functions, and evaluate as a disease-specific marker. It was found that peroxynitrite nitrated IL-18 at tyrosine residues, resulting the dysfunction of IL-18 such as insulin signal transduction and IFN inducing ability. Furthermore, nitrated IL-18 was found in db/db mice, animal model of diabetes mellitus. These results suggested that nitrated IL-18 maybe involved in the development of diabetes mellitus. Nitrated IL-18 has the possibility to be a diabetes-specific marker because of its unique structure.
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