Investigation of the effect of selective COX-2 inhibitor for discogenic pain.
| Project/Area Number |
24790579
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
SAWAJI YASUNOBU 東京医科大学, 医学部, ポストドクター (20571152)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経成長因子 / 椎間板性腰痛 / 選択的COX-2阻害剤 / プロスタグランジン / 軟骨変性 / 神経侵入 / 炎症 / 神経進入 / 腰痛 / 椎間板変性 / NGF / MMP / NSAIDs / Prostaglandin |
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| Research Abstract |
Degeneration of the disc by matrix metalloproteinases (MMPs) and following innervation of the peripheral nerve fiber by nerve growth factor (NGF) are considered as the molecular mechanism of developing discogenic pain. The effect of a selective COX-2 inhibitor, which is often used for managing low back pain in clinic, on the regulation of NGF and MMPs was investigated in isolated human intervertebral disc cells.
Inflammatory cytokine-induced NGF and MMPs expressions were augmented when the cells were treated with a selective COX-2 inhibitor, suggesting that inhibition of COX-2 activity may accelerate both disc degeneration and innervation.
These findings may need to be carefully taken into account when treating patients with discogenic pain.
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Report
(3 results)
Research Products
(24 results)
