| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We previously reported that cut of the infraorbital nerve (IONC) recruits additional excitatory medial lemniscal fibers onto somatosensory thalamic neurons (VPM neurons) within a week. On the other hand, it is also reported that peripheral nerve injury induces remodeling in the central nervous system through functional changes of inhibitory GABA system. However, it remains unclear whether the remodeling of lemniscal fibers onto a VPM neuron after the IONC is mediated by postoperative changes in inhibitory GABA currents. Here we report that the IONC markedly enhanced the amplitude of tonic GABA currents onto a VPM neuron that had multiple lemniscal fibers by the IONC. Moreover, we found that lack of tonic GABA currents by lentivirus vector prevented the remodeling of lemniscal fibers onto a VPM neuron after the IONC. These results indicate that the remodeling of lemniscal fibers onto a VPM neuron after the IONC is mediated by enhanced tonic GABA inhibition by the IONC.
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