Electrophysiological analysis for pain response by the lateral bed nucleus stria terminalis
| Project/Area Number |
24790583
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | St. Marianna University School of Medicine |
|---|
Principal Investigator |
HAGIWARA Hiroko 聖マリアンナ医科大学, 医学部, 助教 (90468207)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | ホルマリンテスト / マウス / 分界条床核外側部 / CRH / GFP / パッチクランプ / スライス / 性差 / CRHニューロン / 情動 / 痛み / ホルマリン / ドーパミンニューロン |
|---|
| Research Abstract |
We discovered that the lateral bed nucleus stria terminalis (BST) is involved in the pain response during formalin test. Conversely, the function of the lateral BST influences the pain response by the formalin. This concept indicates the emotion and pain is related to each other. CRH neurons are expressed the brain area such as the periventricular hypothalamus associated with stress and the central amygdala related to outflow of the emotional response. Thus, CRH neurons in the lateral BST may be involved in emotion side during the formalin test. To this end we must label CRH neurons as fluorescence since we will analyze by patch-clamp technique. So we are now generating transgenic mouse which CRH neurons have bright fluorescence and useful for electrical analyse.
|
Report
(3 results)
Research Products
(4 results)
