Study on role of protein nitrosylation in the nitric oxide-mediated prevention of asthma

• Project/Area Number: 24790587
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene
• Research Institution: Yamaguchi University (2013); Okayama University (2012)
• Principal Investigator: TAKAHASHI Hidekazu 山口大学, 医学(系)研究科(研究院), 講師 (90450402)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 予防医学 / 喘息 / 一酸化窒素 / マウス / ニトロソ化タンパク質

Research Abstract

The goal of this study is to develop a novel method to prevent asthma. It is known that nitric oxide plays key roles in asthma. Nitric oxide is known to function as a bronchodilator. However, the detailed mechanisms of action remain incompletely understood. This study examined, using a murine model of asthma, the changes in the concentrations of nitric oxide-modified proteins and other nitric oxide-derived small molecules. Nitric oxide-modified proteins and other nitric oxide-derived molecules were rather increased in asthma.

Research Products

• [Journal Article] Anti-inflammatory effect of arginase inhibitor and corticosteroid on airway allergic reactions in a Dermatophogoides farinae-induced NC/Nga mouse model (2013)
  • Author(s): Ogino K, Kubo M, Takahashi H, Zhang R, Zou Y, Fujikura Y
  • Journal Title: Inflammation Volume: Vol. 36 Issue: 1 Pages: 141-151
  • DOI: 10.1007/s10753-012-9529-3
  • Peer Reviewed
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~kouei/
• [Remarks] 山口大学医学系研究科環境統御健康医学分野
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~kouei/