Study on role of protein nitrosylation in the nitric oxide-mediated prevention of asthma
Project/Area Number |
24790587
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Hygiene
|
Research Institution | Yamaguchi University (2013) Okayama University (2012) |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 予防医学 / 喘息 / 一酸化窒素 / マウス / ニトロソ化タンパク質 |
Research Abstract |
The goal of this study is to develop a novel method to prevent asthma. It is known that nitric oxide plays key roles in asthma. Nitric oxide is known to function as a bronchodilator. However, the detailed mechanisms of action remain incompletely understood. This study examined, using a murine model of asthma, the changes in the concentrations of nitric oxide-modified proteins and other nitric oxide-derived small molecules. Nitric oxide-modified proteins and other nitric oxide-derived molecules were rather increased in asthma.
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Report
(3 results)
Research Products
(3 results)