Hypotensive effects of Umezu polyphenols among hypertensive patients without medication

• Project/Area Number: 24790590
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene
• Research Institution: Wakayama Medical University
• Principal Investigator: TAKEMURA Shigeki 和歌山県立医科大学, 医学部, 助教 (70511559)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 梅酢ポリフェノール / 高血圧 / ランダム化比較試験 / 一次予防 / 抗酸化作用

Outline of Final Research Achievements

In this study project, we evaluated hypotensive and other beneficial effects of Umezu polyphenols (UP) among hypertensive patients without medication.
In the FY 2012 pilot study, adherence and safety of UP were confirmed. In the FY 2013 double-masking randomized placebo-controlled trial among community-dwelling indivisuals, although the antihypertensive effects of UP were limited, the physical component summary score of the SF-8 self-administered questionnaire improved in the UP group compared with the placebo group. In FY 2014, we followed up the participants of the FY 2013 study for one year with mail questionnaires to find that the improved SF-8 summary score gradually decreased back to the initial level within one year.
In conclusion, some physical beneficial effects of UP were revealed.

Research Products

• [Journal Article] Safety and adherence of Umezu polyphenols in the Japanese plum (Prunus mume) in a 12-week double-blind randomized placebo-controlled pilot trial to evaluate antihypertensive effects. (2014)
  • Author(s): Takemura S, Yoshimasu K, Fukumoto J, Mure K, Nishio N, Kishida K, Yano F, Mitani T, Takeshita T, Miyashita K.
  • Journal Title: Environ Health Prev Med. Volume: 19 Issue: 6 Pages: 444-451
  • DOI: 10.1007/s12199-014-0404-8
  • NAID: 50009331973
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Are Umezu polyphenols in the Japanese plum (Prunus Mume) protective against mild hypertension and oxidation ? Evidence from a double-blind randomized placebo-controlled trial. (2013)
  • Author(s): Takemura S, Yoshimasu K, Mure K, Fukumoto J, Nishio N, Kitano N, Kishida K, Yano F, Mitani T, Takeshita T, Miyashita K.
  • Journal Title: Open Journal of Preventive Medicine. Volume: 3 Issue: 09 Pages: 561-569
  • DOI: 10.4236/ojpm.2013.39075
  • Peer Reviewed
• [Presentation] 薬物治療を受けていない地域在住高血圧患者における梅酢ポリフェノールの降圧作用 (2014)
  • Author(s): 竹村重輝，吉益光一，津野香奈美，黒田基嗣，岸田邦博，矢野史子，三谷隆彦，有田幹雄，宮下和久
  • Organizer: 第12回果実酒・果実飲料と健康に関する研究会
  • Place of Presentation: 和歌山県立医科大学医学部（和歌山市）
  • Year and Date: 2014-11-29
• [Presentation] 薬物治療を受けていない地域在住高血圧患者における梅酢ポリフェノールの降圧作用 (2014)
  • Author(s): 竹村重輝，吉益光一，津野香奈美，黒田基嗣，有田幹雄，宮下和久
  • Organizer: 第73回日本公衆衛生学会総会
  • Place of Presentation: 宇都宮東武ホテルグランデ（宇都宮市）
  • Year and Date: 2014-11-05 – 2014-11-07
• [Presentation] 薬物治療を受けていない高血圧患者における梅酢ポリフェノールの降圧作用：予備試験 (2013)
  • Author(s): 竹村重輝，吉益光一，福元仁，北野尚美，西尾信宏，牟礼佳苗，竹下達也，有田幹雄，宮下和久
  • Organizer: 第72回日本公衆衛生学会総会
  • Place of Presentation: 三重県総合文化センター（津市）
• [Presentation] 薬物治療を受けていない高血圧患者における梅酢ポリフェノールの降圧作用：12週間の予備試験
  • Author(s): 竹村重輝，吉益光一，福元仁，北野尚美，西尾信宏，牟礼佳苗，岸田邦博，矢野史子，三谷隆彦，竹下達也，有田幹雄，宮下和久
  • Organizer: 第11回果実酒・果実飲料と健康に関する研究会
  • Place of Presentation: 近畿大学生物理工学部（和歌山県紀の川市）
• [Presentation] 薬物治療を受けていない高血圧患者における梅酢ポリフェノールの降圧作用―８週までの経過報告―
  • Author(s): 竹村重輝、福元仁、吉益光一、北野尚美、西尾信宏、牟礼佳苗、岸田邦博、矢野史子、三谷隆彦、竹下達也、有田幹雄、宮下和久
  • Organizer: 第10回果実酒・果実飲料と健康に関する研究会
  • Place of Presentation: 和歌山県立医科大学（和歌山市）