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Development of hybrid screening system for barrier-disrupted and immune-activated substance

Research Project

Project/Area Number 24790596
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene
Research InstitutionSetsunan University

Principal Investigator

KAKUTANI Hideki  摂南大学, 薬学部, 助教 (00581414)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアレルギー応答 / 腸管バリア / バリア機能
Research Abstract

It is suggested that the immune diseases such as allergies causes it with the disruption of epithelial cell barrier. In this study, we performed the basic data for development of the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time. It was observed that various environmental pollutants were decreased barrier function, and disrupted the immune response. There results suggest the possibility to develop the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2013 2012

All Presentation (19 results)

  • [Presentation] Orally exposure with dioxins facilitates OVA-specific immunoglobulin production2013

    • Author(s)
      Hideki Kakutani, 他1名
    • Organizer
      第42年会日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Dioxins and their related compounds weaken tight junction as epithelial barrier with decrease of claudin in Caco-2 cells2013

    • Author(s)
      Souichi Ohta, Hideki Kakutani, 他2名
    • Organizer
      33th International Symposium on Halogenated Persistent Organic Pollutant
    • Place of Presentation
      Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Observation of antigen-specific immunoglobulin production in 70-days long-term TCDD-exposed mice sensitized without adjuvants2013

    • Author(s)
      Hideki Kakutani, 他3名
    • Organizer
      33th International Symposium on Halogenated Persistent Organic Pollutant
    • Place of Presentation
      Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス授乳期のTCDD曝露の有無による免疫機能に対する毒性影響2013

    • Author(s)
      角谷秀樹, 他3名
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸管ループ法を用いた環境・食品汚染物質による生体バリア破綻能の比較2013

    • Author(s)
      西本貴樹、角谷秀樹, 他3名
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 塩素・臭素化ダイオキシン類の薬物代謝酵素誘導能2013

    • Author(s)
      角谷秀樹, 他4名
    • Organizer
      第133年会日本薬学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] マウス授乳期のTCDD曝露の有無による免疫機能に対する毒性影響2013

    • Author(s)
      角谷秀樹、秋山恵麻、中尾晃幸、太田壮一
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学府中キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腸管ループ法を用いた環境・食品汚染物質による生体バリア破綻能の比較2013

    • Author(s)
      西本貴樹、角谷秀樹、秋山恵麻、中尾晃幸、太田壮一
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学府中キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Observation of antigen-specific immunoglobulin production in 70-days long-term TCDD-exposed mice sensitized without adjuvants2013

    • Author(s)
      Hideki Kakutani, Ema Akiyama, Teruyuki Nakao, Souichi Ohta
    • Organizer
      33th International Symposium on Halogenated Persistent Organic Pollutants (Dioxin2013)
    • Place of Presentation
      ホテルインターバルゴ テグ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dioxin and their related compounds weaken tight junction as epithelial barrier with decrease of claudin in Caco-2 cells2013

    • Author(s)
      Souichi Ohta, Hideki Kakutani, Ema Akiyama, Teruyuki Nakao
    • Organizer
      33th International Symposium on Halogenated Persistent Organic Pollutants (Dioxin2013)
    • Place of Presentation
      ホテルインターバルゴ テグ
    • Related Report
      2013 Annual Research Report
  • [Presentation] TCDDの長期連続投与による抗原特異的な抗体産生の推移2012

    • Author(s)
      山本翔、角谷秀樹, 他3名
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      武庫川女子大学
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体膜破綻能を指標とした環境汚染物質の毒性評価2012

    • Author(s)
      山下治子、角谷秀樹, 他3名
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      武庫川女子大学
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Damaging effect of tight junctions as barrier function in Caco-2 cells indicated by dioxins and their related compounds2012

    • Author(s)
      Hideki Kakutani, 他3名
    • Organizer
      32th International Symposium on Halogenated Persistent Organic Pollutant
    • Place of Presentation
      Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] ダイオキシン類が有する免疫攪乱作用の検討-70日連続投与ダイオキシン類による抗原特異的な抗体産生変動-2012

    • Author(s)
      角谷秀樹, 他5名
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      愛媛県県民文化会館
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Dextran透過を指標としたTCDDとB(a)Pによる生体膜破綻作用2012

    • Author(s)
      太田壮一、角谷秀樹, 他5名
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      愛媛県県民文化会館
    • Related Report
      2013 Final Research Report
  • [Presentation] Dextran透過を指標としたTCDDをB(a)Pによる生体膜破綻作用2012

    • Author(s)
      太田壮一
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      愛媛県県民文化会館
    • Related Report
      2012 Research-status Report
  • [Presentation] Damaging effect of tight junctions as barrier function in Caco-2 cells indicated by dioxins and their related compounds2012

    • Author(s)
      Hideki Kakutani
    • Organizer
      32th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      Cairns Convention Centre
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体膜破綻能を指標とした環境汚染物質の毒性評価2012

    • Author(s)
      山下治子
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      武庫川女子大学浜甲子園キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] TCDDの長期連続投与による抗原特異的な抗体産生の推移2012

    • Author(s)
      山本翔
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      武庫川女子大学浜甲子園キャンパス
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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