Does high sensitive troponin T predict the new onset of atrial fibrillation?

• Project/Area Number: 24790597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene
• Research Institution: Kurume University
• Principal Investigator: ANEGAWA Takahiro 久留米大学, 医学部, 助教 (00511833)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 心房細動 / 高感度トロポニンT / サロゲートマーカー / 予防医学 / 疫学

Research Abstract

The early detection of atrial fibrillation (AF) is important for high risk individuals. However, the biomarkers which predict the new onset of AF have not been reported.
We considered that high sensitive cardiac troponin T (hsTnT) could be a biomarker to predict the new onset of AF. The purpose of this study is to identify a causal relationship between hsTnT and AF. We analyzed the subjects who received a health examination in a small community (Uku town, Nagasaki, Japan) and went into Kurume University Hospital for a complete physical examination.
In cross sectional study, we found that hsTnT was associated independently with AF, and the prevalence of AF was closely correlated with hsTnT levels. We confirmed the prognosis as a longitudinal study. We examine the relationship between the new onset of AF and hsTnT.

Research Products

• [Journal Article] Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats (2013)
  • Author(s): Yasuoka S, Kai H, Kajimoto H, Kudo H, Takayama N, Anegawa T, Koga M, Miyamoto T, Mifune H, Kage M, Hirooka Y, Imaizumi T
  • Journal Title: Circulation Journal Volume: 77(6) Pages: 1474-1481
  • Peer Reviewed
• [Journal Article] Respiratory variation of vertebral arterial flow in a patient scheduled for coronary artery bypass graft surgery : lesson from atypical subclavian steal phenomenon (2013)
  • Author(s): Anegawa T, Kai H, Fukuda K, Iwamoto Y, Tsuru T, Itaya N, Koiwaya H, Takeuchi T, Toyama Y, Oba T, Mawatari K, Takeuchi Y, Morioka M, Tanaka H, Ueno T, Imaizumi T
  • Journal Title: Circulation Journal Volume: 77(9) Pages: 2412-2414
  • Peer Reviewed
• [Journal Article] マイクロコンベックス型探触子を用いた経口腔頸部血管超音波検査法(modified TOCU) (2013)
  • Author(s): 3姉川敬裕、福田賢治、甲斐久史、崎間洋邦、矢坂正弘、梶本英美、岩元美子、安岡逸、青木裕司、打和大幹、岡田靖、今泉勉
  • Journal Title: 脳卒中 Volume: (in press) Pages: 35-1
  • Peer Reviewed
• [Journal Article] Respiratory Variation of Vertebral Arterial Flow in a Patient Scheduled for Coronary Artery Bypass Graft Surgery (2013)
  • Author(s): Takahiro Anegawa
  • Journal Title: Circulation Journal Volume: 77 Issue: 9 Pages: 2412-2414
  • DOI: 10.1253/circj.CJ-13-0071
  • NAID: 10031191772
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] マイクロコンベックス型探触子を用いた経口腔頸部血管超音波検査法（modified TOCU） (2013)
  • Author(s): 姉川敬裕
  • Journal Title: 脳卒中 Volume: 35 Pages: 1-4
  • NAID: 130004873575
  • Peer Reviewed
• [Journal Article] Highly Sensitive Troponin T is Associated with Atrial Fibrillation in a General Population (2012)
  • Author(s): Anegawa T, Kai H, Adachi H, Hirai Y, Enomoto M, Fukami A, Otsuka M, Kajimoto H, Yasuoka S, Iwamoto Y, Aoki Y, Fukuda K, Imaizumi T
  • Journal Title: Int J Cardiol Volume: 156(1) Pages: 98-100
  • Peer Reviewed
• [Journal Article] Stent-anchored coil embolotherapy - novel treatment procedure for huge pulmonary arterio-venous malformation in hereditary hemorrhagic telangiectasia (2012)
  • Author(s): Koiwaya H, Kai H, Ueno T, Niiyama H, Takeuchi T, Ueda S, Gondo T, Kumagai E, Miyamoto M, Yokoyama S, Sasaki K, Toyama Y, Ohtsuka M, Mitsutake Y, Anegawa T, Nakayoshi T, Kudo Y, Suda K, Imaizumi T
  • Journal Title: Int J Cardiol Volume: 157(1) Pages: 122-4
  • Peer Reviewed
• [Journal Article] Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure : new effect of asymmetric dimethylarginine (2012)
  • Author(s): Kajimoto H, Kai H, Aoki H, Yasuoka S, Anegawa T, Aoki Y, Ueda S, Okuda S, Imaizumi T
  • Journal Title: Kidney Int Volume: 81(8) Pages: 762-8
  • Peer Reviewed
• [Journal Article] Transoral Carotid Ultrasonography Using A Micro Convex Probe with B-flow Imaging for Extracranial Internal Carotid Artery Dissection (2012)
  • Author(s): Sakima H, Isa K, Anegawa T, Kokuba K, Nakachi K, Goya Y, Tokashiki T, Ishiuchi S, Ohya Y
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 21(8) Pages: 912-912
  • Peer Reviewed
• [Journal Article] High-sensitive troponin T is associated with atrial fibrillation in a general population. (2012)
  • Author(s): Anegawa T, Kai H, Kajimoto H, YasuokaS
  • Journal Title: Int J Cardiol Volume: 156 Issue: 1 Pages: 98-100
  • DOI: 10.1016/j.ijcard.2011.12.117
  • Peer Reviewed
• [Presentation] 左内頸動脈を逆流し外頸動脈系へのUターンを呈したマカロニサインを有する左総頸動脈閉塞の1例 (2013)
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  • Organizer: 第38回日本脳卒中学会総会
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  • Year and Date: 2013-03-23
• [Presentation] 左内頸動脈を逆流し、外頸動脈系へのUターンを呈した、マカロニサインを有する左総頸動脈閉塞の1例 (2013)
  • Author(s): 姉川敬裕
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• [Presentation] 非弁膜性心房細動を有する脳梗塞患者からみたCHADS_2スコア,CHA_2DS_2-VAScスコア (2012)
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  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2012-09-20
• [Presentation] 非弁膜性心房細動を有する脳梗塞患者からみたCHADS_2スコア,CHA_2DS_2-VAScスコア (2012)
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  • Organizer: 第60回日本心臓病学会学術集会
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  • Year and Date: 2012-09-16
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  • Organizer: 第112回日本循環器学会九州地方会
  • Place of Presentation: 沖縄
  • Year and Date: 2012-06-30
• [Presentation] 椎骨動脈血流波形が呼気時に逆行、吸気時に順行と呼吸性変動を示した左鎖骨下動脈盗血現象 (2012)
  • Author(s): 姉川敬裕,福田賢治,甲斐久史,岩元美子,津留智子,青木裕司,打和大幹,竹内靖治,森岡基浩,今泉勉
  • Organizer: 第37回日本脳卒中学会総会
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  • Year and Date: 2012-04-28
• [Presentation] 非弁膜性心房細動を有する脳梗塞患者からみたCHADS2スコア，CHA2DS2-VAScスコア (2012)
  • Author(s): 姉川敬裕
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 金沢
• [Presentation] 非弁膜性心房細動を有する脳梗塞患者からみたCHADS2スコア，CHA2DS2-VAScスコア (2012)
  • Author(s): 姉川敬裕
  • Organizer: 第35回日本高血圧学会総会
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• [Presentation] 左椎骨動脈血流波形が呼気時に逆行、吸気時に順行と呼吸性変動を示した左鎖骨下動脈盗血現象の一例 (2012)
  • Author(s): 姉川敬裕
  • Organizer: 第37回日本脳卒中学会総会
  • Place of Presentation: 福岡