| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
We carried out an epidemiological study to elucidate the association between SNPs and obesity (Body Mass Index(BMI)≧27.5) on 3648 Japanese male workers. We detected three SNPs of beta3 adrenergic receptor, beta2 adrenergic receptor and uncoupling protein-1. We observed important findings on the association between SNP and obesity.
Significant changes weren’t found in average of basic characteristic variable, including BMI on each SNP. Next, we evaluated the contribution of genetic risk score, defined as the sum of alleles that increase the risk of obesity, by logistic regression analysis. The odds ratio of the genetic risk score ≧1 group was significant higher than that of genetic risk score=0 group. We indicated that the combination of 3 SNPs may be stronger associated with obesity compared with each one.
|
