Analysis of osteoprotegerin gene expression in regard to cardiac sudden death
| Project/Area Number |
24790640
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
Takeshi Kondo 神戸大学, 医学(系)研究科(研究院), 講師 (20335441)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | OPG / RANKL / 心臓性突然死 / 法医解剖 |
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| Outline of Final Research Achievements |
Osteoblasts/stromal cells secrete osteoprotegerin (OPG), which is a soluble member of the TNF receptor superfamily. OPG acts as a decoy receptor for RANKL, thereby preventing its interaction with the cognate receptor RANK. OPG is known to be expressed not only in bone tissue but also in many other tissue types, including myocardium. Recently, OPG has been reported to be associated with various cardiac diseases. The present study analyzed the serum OPG concentration in forensic autopsy cases (including those of cardiac sudden death). In particular, the expression of OPG and its receptor RANK were evaluated by immunohistochemistry of the myocardium. The results of this study will be presented in the 100th Congress of the Japanese Society of Legal Medicine (Tokyo, 2016). In addition, a collaborative study regarding mouse OPG gene expression and the sFRP gene has been published in PLOS ONE (Mori et al. 2014).
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Report
(5 results)
Research Products
(7 results)
