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Development of histopathological diagnosis method by MR histology image of a postmortem human brain using

Research Project

Project/Area Number 24790648
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Legal medicine
Research InstitutionNational Defense Medical College

Principal Investigator

KANAWAKU Yoshimasa  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (80465343)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords法医学 / MR組織学 / 画像診断 / 法医解剖 / ホルマリン固定 / 法医診断 / 磁気共鳴画像 / MRI / MR組織学
Outline of Final Research Achievements

The aim of this study is to investigation the feasibility of MR histology, which deals with formalin-fixed samples, to forensic practice. The tissues taken in forensic autopsy were used for experiments. In addition to the measurement of relaxation times of the fixed samples, we performed the MR histology scanning with a clinical MR equipment and comparison MR histology images and pathological specimens of the hippocampal region. Though we found that the relaxation time of the fixed organ is able to be affected to the formalin fixation process, it is considered that the measurement result must be regarded as a preliminary data for the future of research. It is found that MR histology image acquired with clinical MR apparatus can be valuable for forensic practice and research. Although the scanning technique and diagnostic application of MR histology image will continue to be considered, MR histology would be expected to be applied of the forensic practice

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] High-resolution 3D-MRI of postmortem brain specimens fixed by formalin and gadoteridol2014

    • Author(s)
      Kanawaku Y, Someya S, Kobayashi T, Hirakawa K, Shiotani S, Fukunaga T, Ohno Y, Kawakami S, Kanetake J
    • Journal Title

      Legal Medicine

      Volume: 16 Pages: 323-328

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution 3D-MRI of postmortem brain specimens fixed by formalin and gadoteridol2014

    • Author(s)
      Kanawaku Y, Someya S, Kobayashi T, Hirakawa K, Shiotani S, Fukunaga T, Ohno Y, Kawakami S, Kanetake J.
    • Journal Title

      Legal Medicine

      Volume: 印刷中 Issue: 4 Pages: 218-221

    • DOI

      10.1016/j.legalmed.2014.03.003

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 認知機能障害が急速に進行した成人Down症候群者にみられた肺動脈血栓塞栓症2014

    • Author(s)
      金涌佳雅,原田一樹,金武潤,新井信隆,竹内千仙,望月葉子,福永龍繁
    • Organizer
      第83回日本法医学会関東地方
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 剖検摘出固定脳のMRI撮像法の検討2013

    • Author(s)
      金涌佳雅,染谷聡香,小林智哉,平川 慶子,早川 秀幸,大野 曜吉,中津海 学子,原田 一樹,塩谷 清司,金武 潤
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 海馬領域を対象としたホルマリン固定脳のMR画像検査の検討2013

    • Author(s)
      金涌佳雅,染谷聡香,小林智哉,河上早,早川 秀幸,平川 慶子,塩谷 清司,大野 曜吉,福永龍繁,原田 一樹,金武 潤
    • Organizer
      第41回日本磁気共鳴医学会大会
    • Place of Presentation
      徳島
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト剖検摘出臓器のMRI技術の基礎的研究(第一報):死後変化とホルマリン固定が緩和時間に与える影響2012

    • Author(s)
      金涌佳雅
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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