Neural underpinnings of the model of cognitive dysfunction in patients with breast cancer and development of cognitive rehabilitation.

• Project/Area Number: 24790653
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: SEKIGUCHI Atsushi 東北大学, 東北メディカル・メガバンク機構, 非常勤講師 (50547289)
• Co-Investigator(Renkei-kenkyūsha): SATO Chiho 東北大学, 大学病院, 医員 (50746667) ; TAKEUCHI Hikaru 東北大学, 加齢医学研究所, 准教授 (50598399)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 脳・神経 / 乳がん / 認知機能障害 / 内分泌療法 / 術後認知機能障害

Outline of Final Research Achievements

Recently, cognitive dysfunctions in patients with breast cancer have been given attention. In this study, we examined postmenopausal females with breast cancer and age-matched controls. We assessed their cognitive functions and performed brain structural MRI before, shortly after, and 6 months after the surgery. We found the thalamic volume reduction and the attentional dysfunction shortly after surgery as early responses to anesthesia. In addition, these changes in patient without any adjuvant therapy recovered 6 months after surgery, whereas those in patients with an adjuvant hormonal therapy did not. We hypothesized that general anesthesia impacts the brain and its functions in cancer survivors. However, most survivors would recover after surgery if not exposed to other risk factors, including hormonal therapy. As for the cognitive rehabilitation, we failed to find a significant effect of a brain training game on the attentional function in normal elderly subjects.

Research Products

• [Journal Article] Postoperative structural brain change and cognitive dysfunction in patients with brest cancer (2015)
  • Author(s): Sato C*, Sekiguchi A*, Kawai M, Kotozaki Y, Nouchi R, Tada H, Takeuchi H, Ishida T, Taki Y, Kawashima R, Ohuchi N (*equal contribution)
  • Journal Title: PLoS ONE Volume: 10(11) Issue: 11 Pages: e0140655-e0140655
  • DOI: 10.1371/journal.pone.0140655
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 脳MRIを用いた初発乳癌術後半年の視床体積における神経可塑性の検討 (2016)
  • Author(s): 佐藤千穂, 関口敦, 松平泉, 事崎由佳, 野内類, 竹内光, 瀧靖之, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪府、大阪市）
  • Year and Date: 2016-04-14
• [Presentation] Recovery from brain volume reduction and cognitive dysfunctions 6 months after surgery in patients with breast cancer (2016)
  • Author(s): Sekiguchi A, Sato C, Kawai M, Ishida T, Taki Y, Ohuchi N, Kawashima R
  • Organizer: The 74th Annual Meeting of the American Psychosomatic Society
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2016-03-09
  • Int'l Joint Research
• [Presentation] Neural plasticity of the thalamic volume 6 months after surgical operations in patients with breast cancer (2015)
  • Author(s): Sato C, Sekiguchi A, Matsudaira I, Kotozaki Y, Nouchi R, Takeuchi H, Taki Y, Kawai M, Tada H, Ishida T, Kawashima R, Ohuchi N
  • Organizer: The 21st Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] 脳MRIを用いた乳がん手術前後の脳構造変化および認知機能障害の検討 (2015)
  • Author(s): 佐藤千穂, 関口敦, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2015-04-16 – 2015-04-18
• [Presentation] 脳MRIを用いた乳癌手術前後の脳構造変化および認知機能障害の検討 (2015)
  • Author(s): 佐藤千穂, 関口敦, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-04-16
• [Presentation] 乳がん手術前後の脳構造変化および認知機能障害～縦断研究による検討 (2014)
  • Author(s): 佐藤千穂, 関口敦, 事崎由佳, 野内類, 竹内光, 瀧靖之, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明
  • Organizer: 第78回日本心身医学会東北地方会
  • Place of Presentation: 仙台
• [Presentation] Neural underpinnings of postoperative cognitive dysfunctions (POCD) in patients with breast cancer (2014)
  • Author(s): Sato C, Sekiguchi A, Kotozaki Y, Nouchi R, Takeuchi H, Taki Y, Kawai M, Tada H, Ishida T, Kawashima R, Ohuchi N
  • Organizer: The 72nd Annual Meeting of the American Psychosomatic Society
  • Place of Presentation: San Francisco, USA
• [Presentation] 乳癌患者における術後認知機能障害の神経基盤の検討 (2013)
  • Author(s): 佐藤千穂, 関口敦, 事崎由佳, 野内類, 竹内光, 瀧靖之, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡