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Silent cerebrovascular lesions of the elderly and longitudinal decline of higher-level daily functions.

Research Project

Project/Area Number 24790654
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTohoku University

Principal Investigator

Tomita Naoki  東北大学, 大学病院, 助教 (00552796)

Co-Investigator(Renkei-kenkyūsha) TSUBOTA Megumi  岩手医科大学, 医学部, 講師 (20419998)
SATOH Michihiro  東北大学, 大学病院, 特別研究員(PD) (70717892)
OHKUBO Takayoshi  帝京大学, 医学部, 教授 (60344652)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords大脳白質病変 / 無症候性脳梗塞 / 脳萎縮 / 無症候性脳出血 / 脳微小出血 / 手段的ADL / 老年症候群 / 脳委縮 / 微小脳出血 / ラクナ梗塞 / 無症候性脳血管障害 / データベース
Outline of Final Research Achievements

At the community-based cohort, both lacunar infarcts and white matter hyperintensity were significantly associated with the decline of higher-level daily functions after 7-year follow-up. Lacunar infarcts were strongly associated with the decline, rather than white matter hyperintensity. Lacunar infarcts were related to decline in intellectual activity.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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