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Search for Therapeutic Drugs Against Ulcerative Colitis-Mechanism Elucidation of Daikenchuto

Research Project

Project/Area Number 24790657
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of Toyama

Principal Investigator

HAYASHI Shusaku  富山大学, 和漢医薬学総合研究所, 助教 (10548217)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords潰瘍性大腸炎 / 大腸炎関連発がん / 腸管粘膜免疫 / 腸管マクロファージ / 炎症性腸疾患 / マクロファージ
Research Abstract

Daikenchuto (DKT) is a traditional Japanese medicine composed of four medicinal herbs. In the present study, we examined the effect of DKT on dextran sodium sulfate (DSS)-induced experimental colitis and colitis-associated cancer (CAC) in mice and investigated the underlying mechanisms of the protective action.
DKT reduced the severity of DSS-induced colitis and the elevation of inflammatory cytokines in the colon of colitis mice. In addition, DKT suppressed the expression of TNF-alpha on the intestinal macrophages of inflamed colonic mucosa. Interestingly, DKT significantly reduced the number and size of colonic tumors in mice with CAC. The present study demonstrates that DKT suppresses acute colitis and colitis-associated tumorigenesis. Furthermore, it is presumed that DKT downregulates the expression of inflammatory mediators, thereby reducing the colonic tumorigenesis associated with chronic colitis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model2014

    • Author(s)
      Yamamoto T., Kodama T., Lee J., Utsunomiya N., Hayashi S., Sakamoto H., Kuramoto H., Kadowaki M.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: 85888-85888

    • DOI

      10.1371/journal.pone.0085888

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cinacalcet a Calcimimetic, Prevents Nonsteroidal Anti- inflammatory Drug–Induced Small Intestinal Damage in Rats2013

    • Author(s)
      Hayashi S, Kurata N, Kitahirachi E, Nishimura Y, Amagase K, Yano T, Takeuchi K.
    • Journal Title

      J Physiol Pharmacol

      Volume: 64 Pages: 453-463

    • URL

      http://www.jpp.krakow.pl/journal/archive/08_13/pdf/453_08_13_article.pdf

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2 contributes to antigen-stimulated Ca2+ influx in mucosal mast cells2013

    • Author(s)
      Oda S., Uchida K., Wang X., Lee J., Shimada Y., Tominaga M., Kadowaki M.
    • Journal Title

      Pflugers Archiv : European journal of physiology

      Volume: 465 Issue: 3 Pages: 895-900

    • DOI

      10.1016/j.bbrc.2012.12.058

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice2012

    • Author(s)
      Wang X, Kageyama-Yahara N, Hayashi S, Yamamoto T, Kadowaki M.
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: 2012 Pages: 862743-862743

    • DOI

      10.1155/2012/862743

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ニコチンはIL-6/Stat3経路の阻害を介して大腸炎関連発がんを抑制する2014

    • Author(s)
      林周作,濱田貴之,石井陽子,笹原正清,門脇真
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Nicotine Suppresses Colonic Tumorigenesis Associated with Chronic Colitis through the Inhibition of IL-6/Stat3 Pathway in Mice2014

    • Author(s)
      Shusaku Hayashi, Takayuki Hamada, Yoko Ishii, Masakiyo Sasahara, Makoto Kadowaki
    • Organizer
      Digestive Disease Week 2014
    • Place of Presentation
      Chicago, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] DSS誘起大腸炎モデルマウスにおける腸管マクロファージの機能制御を介したPI3K p85αの役割2013

    • Author(s)
      濱田貴之,林周作,門脇真
    • Organizer
      日本薬学会北陸支部第125回例会
    • Place of Presentation
      金沢
    • Year and Date
      2013-11-17
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Nicotine Suppresses Colonic Tumorigenesis Associated with Chronic Colitis in Mice through the Inhibition of IL-6 and TNF-αExpression2013

    • Author(s)
      Hayashi S, Hamada T, Kadowaki M
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando, USA.
    • Related Report
      2013 Final Research Report
  • [Presentation] ニコチンは大腸炎関連発がんの形成を抑制する2013

    • Author(s)
      林周作,濱田貴之,門脇真
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Nicotine suppresses colonic tumorigenesis associated with chronic colitis in mice through the inhibition of IL-6 and TNF-α expression2013

    • Author(s)
      Shusaku Hayashi、Takayuki Hamada、Makoto Kadowaki
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando、USA
    • Related Report
      2012 Research-status Report
  • [Presentation] a7ニコチン受容体によるJAK2-カスパーゼの活性を介した形質細胞様樹状細胞遊走抑制作用2012

    • Author(s)
      山本武,金内優也,林周作,門脇真
    • Organizer
      第14回日本神経消化器病学会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Shikonin suppresses the activation of mucosal mast cells through the inhibition of nuclear orphan receptors NR4A expression2012

    • Author(s)
      Hayashi S, Wang X, Umezaki M, Yamamoto T, Kadowaki M.
    • Organizer
      5th International Symposium on Scientific Research of Traditional Medicine
    • Place of Presentation
      富山
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 紫雲膏の主要活性成分シコニンの核内オーファン受容体NR4Aの遺伝子発現抑制を介したマスト細胞に対する作用2012

    • Author(s)
      王暁宇,林周作,山本武,門脇真
    • Organizer
      第29回和漢医薬学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] マウスDSS誘起大腸炎におけるPI3K p85αサブユニットの役割2012

    • Author(s)
      林周作,大城百恵,山本武,門脇真
    • Organizer
      第49回日本消化器免疫学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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