| Project/Area Number |
24790659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka City University |
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Principal Investigator |
TANAKA Fumio 大阪市立大学, 医学(系)研究科(研究院), 後期臨床研究医 (20623292)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ストレス / 神経科学 / 機能性ディスペプシア / 前向き探索的研究 |
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| Research Abstract |
Design: A clinical assessment and a duodenal biopsy specimens were obtained from 6 patients with functional dyspepsia (FD) and 3 healthy subjects. Mucosal expressions of glial cell line-derived neurotrophic factor (GDNF) protein and intercellular space between duodenal epithelial cells were evaluated. Results: Compared with healthy subjects, FD patients exhibited: (a) high symptom severities which belong to postprandial distress syndrome and somatization; (b) increased expression of GDNF protein; and (c) dilated intercellular space. The expression of GDNF was positively correlated with intercellular space. The expression of GDNF had a tendency of positive correlation with symptoms such as postprandial distress. Conclusions: The duodenal mucosa of FD patients displays increased expression of GDNF associated with dilated intercellular space, which may be a pathophysiological mechanism of clinical symptoms.
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