• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The system of neurosteroid synthesis regulates the depressive-like behavior

Research Project

Project/Area Number 24790662
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionWakayama Medical University

Principal Investigator

Yamamoto Yuta  和歌山県立医科大学, 医学部, 助教 (00580672)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsうつ様行動 / 小脳 / マイクロアレイ / パスウェイ解析 / 成長ホルモン / 強制水泳試験 / 遺伝子発現解析 / 前頭前野 / ラット
Outline of Final Research Achievements

Depressive-like behaviors in animals are usually assessed by standardized behavioral tests such as the forced swimming test (FST). However, individual variation in test performance may obscure group differences and thereby hinder the discovery of genes responsible for depression. Few reports have shown the influence of individual variability in identifying the genes associated with depressive-like behaviors. In this study, we conducted microarray analysis to identify genes differentially expressed in the prefrontal cortex (PFC) and cerebellum of rats stratified by FST immobility ratio into a control group and a depressive group. Eleven genes were differentially expressed in both the cerebellum and PFC of the depressive group. Ingenuity Pathway Analysis identified Gh1 as a hub gene in the networks of differentially expressed genes in both brain regions. This study indicates that the depressive-like behavior may be related to the decrease of Gh1 expression in the cerebellum and PFC.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Down-regulation of growth hormone 1 gene in the cerebellum and prefrontal cortex of rats with depressive-like behavior.2015

    • Author(s)
      Yamamoto Y, Ueyama T, Ito T, Tsuruo Y.
    • Journal Title

      Physiological Genomics

      Volume: 0 Issue: 5 Pages: 0-0

    • DOI

      10.1152/physiolgenomics.00119.2014

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alterations of regional cerebral blood flow in tinnitus patients as assessed using single-photon emission computed tomography2015

    • Author(s)
      Ueyama T, Donishi T, Ukai S, Yamamoto Y, Ishida T, Tamagawa S, Hotomi M, Shinosaki K, Yamanaka N, Kaneoke Y
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: e0137291-e0137291

    • DOI

      10.1371/journal.pone.0137291

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 1.うつ行動を制御する小脳-小脳発達阻害モデルによるアプローチ-2016

    • Author(s)
      山本悠太、伊藤隆雄、上山敬司
    • Organizer
      第121 回日本解剖学会総会 2016.3.28 福島県郡山市
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of novel responsible genes for the depressive-like behavior in microarray and pathway analyses2015

    • Author(s)
      Yamamoto Y
    • Organizer
      Catecholamines and other neurptransmitters in stress
    • Place of Presentation
      Smolenice, Slovakia
    • Year and Date
      2015-06-20 – 2015-06-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Identification of Novel Responsible Genes for the Depressive-like Behavior in Microarray and Pathway Analyses.2015

    • Author(s)
      Yamamoto Y and Ueyama T
    • Organizer
      11th Symposium on catecholamine and other neurotransmitters in stress
    • Place of Presentation
      Smolenis, Slovakia
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] うつ様行動を示すラット小脳にてGh1の発現が減少する2015

    • Author(s)
      山本悠太、伊藤隆雄、上山敬司、鶴尾吉宏
    • Organizer
      第3回ニューロカンファレンス和歌山
    • Place of Presentation
      和歌山県和歌山市
    • Year and Date
      2015-01-11
    • Related Report
      2014 Research-status Report
  • [Presentation] うつ様行動を示すラット小脳にてGh1の発現が減少する2014

    • Author(s)
      山本悠太、伊藤隆雄、上山敬司、鶴尾吉宏
    • Organizer
      第36回日本生物学的精神医学会年会
    • Place of Presentation
      奈良県奈良市
    • Year and Date
      2014-09-30
    • Related Report
      2014 Research-status Report
  • [Presentation] DOWN-REGULATION OF GH1 IN DEPRRESIVE-LIKE BEHAVIORAL RAT.2014

    • Author(s)
      Yamamoto Y,Shiba A, Ito T, Ueyama T, Tsuruo Y
    • Organizer
      21st Multidisciplinary International Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
    • Place of Presentation
      St Petersburg, Russia
    • Year and Date
      2014-05-16 – 2014-05-19
    • Related Report
      2014 Research-status Report
  • [Presentation] うつ様を示すラット小脳ではGh1の発現が減少する2014

    • Author(s)
      山本 悠太、志波歩美、伊藤隆雄、上山敬司、鶴尾吉宏
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] DOWN-REGULATION OF GH1 IN DEPRRESIVE-LIKE BEHAVIORAL RAT.2014

    • Author(s)
      Y Yamamoto, A Shiba, T Ito, T Ueyama and Y Tsuruo
    • Organizer
      21st Multidisciplinary International Neuroscience and Biological Psychiatry Conference “Stress and Behavior” ISBS Conference
    • Place of Presentation
      Oktiabrskaya Hotel(St-Petersburg, Russia)
    • Related Report
      2013 Research-status Report
  • [Presentation] うつ様を示すラット小脳ではGh1の発現が減少する2013

    • Author(s)
      山本悠太、志波歩美、伊藤隆雄、上山敬司、鶴尾吉宏
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット脳における7α 水酸化酵素CYP7B1 の局在解析2013

    • Author(s)
      山本悠太、志波歩美、伊藤隆雄、上山敬司、鶴尾吉宏
    • Organizer
      第118 回日本解剖学会総会・全国学術集会
    • Place of Presentation
      かがわ国際会議場(高松市)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi