Molecular mechanism of a vascular calcification in post menopausal women with chronic kidney disease.

• Project/Area Number: 24790666
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kurume University
• Principal Investigator: UCHIWA hiroki 久留米大学, 医学部, 助教 (30624506)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性腎臓病 / 閉経 / 血管石灰化 / 血管内皮機能障害 / 老年医学

Research Abstract

We focused on vascular endothelial dysfunction to study the mechanism of vascular calcification in CKD patient. We would like to clarify to the molecular mechanism of a vascular calcification in post menopausal women with CKD. We investigated vascular calcification in female C57BL/6J mice which underwent 5/6 nephrectomy (NX) and ovariectomy(OVX). Experiments included the following four groups: sham operation; NX; OVX; NX+OVX. Four group did not show calcification in the aorta. We thought that it was necessary to examine in the model of RAS system activation or the model with a high level of serum phosphate.