| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The expression of autophagy on cell line level and mouse level was used for the purpose of the elucidation of the relevance between the function of autophagy in intestinal tract tissues and the pathology of intestinal tract inflammation. In cell line level, the expression of autophagy was checked by induction of inflammatory cytokines. Examination is under continuation about the time course and dose dependency which the expression of autophagy increase by several cytokines. I plan to study about the expression of autophagy by induction of various anti-inflammatory substances. In the mouse level, I checked that the expression of autophagy was increased significantly in the DSS colitis models. And the expression of autophagy decreased in IL-10 knockout mice compared with wild type mice. I created the autophagy knockout mouse which had used for purpose of functional analysis.
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