| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
It is known that hepatitis C virus (HCV)-related hepatocellular carcinoma development is associated with age. In this study, the effect of sirtuin (SIRT) gene, considered age-related, on HCV-related liver pathogenesis was examined. SIRT gene was down-regulated in the human liver cancerous tissue compared to the non-cancerous tissue. There was no effect of SIRT expression on patients age or gender. HCV replication was independent of SIRT gene inhibition or activation in HCV-replicating liver cancer cells. Cellular senescence determined by beta-galactosidase staining is affected by cellular density and possibly by HCV. Although precise mechanisms remain to be elucidated, there might be a relationship between SIRT gene expression and HCV-related hepatocellular carcinoma.
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