Management of antithrombotics during periendoscopic period.

• Project/Area Number: 24790679
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: Satoshi Ono 東京大学, 医学部附属病院, 助教 (40611934)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 消化器内視鏡 / 抗凝固薬 / 抗血小板薬

Outline of Final Research Achievements

Concerning the management of antithrombotics during periendoscopic period, we revealed the safety of endoscopic biopsy on all kinds of antithrombotics and the safety of high-risk endoscopic procedures on aspirin alone. Additionally, we could start new clinical trials about the feasibilities of high-risk endoscopic procedures on thienopyridines or warfarin considering results obtained from these previous studies.

Research Products

• [Journal Article] Current practices in the management of antithrombotics during the periendoscopic period. (2016)
  • Author(s): Ono S, Saito I, Ikeda Y, Fujishiro M, Komuro I, Koike K.
  • Journal Title: International Heart Journal Volume: 57
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Recent clinical management of antithrombotic agents for gastrointestinal endoscopy after revision of guidelines in Japan. (2015)
  • Author(s): Ono S, Fujishiro M, Ikeda Y, Komuro I, Koike K
  • Journal Title: Dig Endosc. Volume: 27 Issue: 6 Pages: 649-656
  • DOI: 10.1111/den.12498
  • Peer Reviewed
• [Journal Article] Thienopyridine derivatives as risk factors for bleeding following high risk endoscopic treatments: Safe Treatment on Antiplatelets (STRAP) study. (2015)
  • Author(s): Ono S, Fujishiro M, Yoshida N, Doyama H, Kamoshida T, Hirai S, Kishihara T, Yamamoto Y, Sakae H, Imagawa A, Hirano M, Koike K.
  • Journal Title: Endoscopy Volume: 47 Issue: 07 Pages: 632-637
  • DOI: 10.1055/s-0034-1391354
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Continuation or discontinuation of antithrombotics in clinical daily practice of gastrointestinal endoscopy: Has a paradigm shift occurred in Japan? (2015)
  • Author(s): Ono S, Koike K.
  • Journal Title: Dig Endosc. Volume: 27 Issue: 1 Pages: 16-7
  • DOI: 10.1111/den.12325
  • Peer Reviewed
• [Journal Article] Which route is accompanied by minimal discomfort when performing esophagogastroduodenoscopy with an ultrathin endoscope, transnasal or transoral? (2014)
  • Author(s): Ono S, Niimi K, Fujishiro M, Takahashi Yu, Sakaguchi Y, Nakayama C, Minatsuki C, Matsuda R, Hirayama-Asada I, Tsuji Y, Mochizuki S, Kodashima S, Yamamichi N, Ozeki A, Matsumoto L, Ohike Y, Yamazaki T, Koike K.
  • Journal Title: World J Gastroenterol. Volume: 20 Issue: 17 Pages: 5045-5050
  • DOI: 10.3748/wjg.v20.i17.5045
  • Peer Reviewed / Open Access
• [Journal Article] Ultrathin endoscope flexibility can predict discomfort associated with unsedated transnasal esophagogastroduodenoscopy. (2013)
  • Author(s): Ono S, Niimi K, Fujishiro M, Nakao T, Suzuki K, Ohike Y, Kodashima S, Yamamichi N, Yamazaki T, Koike K.
  • Journal Title: World J Gastrointest Endosc. Volume: 5 Issue: 7 Pages: 346-351
  • DOI: 10.4253/wjge.v5.i7.346
  • Peer Reviewed
• [Journal Article] Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan. (2012)
  • Author(s): Ono S
  • Journal Title: J Gastroenterol Volume: 47 Issue: 7 Pages: 770-774
  • DOI: 10.1007/s00535-012-0538-7
  • Peer Reviewed
• [Presentation] アスピリン単剤継続下での出血高危険度消化器内視鏡の安全性の検討(多施設共同研究：STRAP試験) (2014)
  • Author(s): 小野敏嗣
  • Organizer: JDDW2014
  • Place of Presentation: 神戸国際展示場・ポートピアホテル・神戸国際会議場
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] THIENOPYRIDINE DERIVATIVE CAN BE A RISK FACTOR FOR POSTOPERATIVE BLEEDING WHEN PERFORMING GASTRIC ENDOSCOPIC SUBMUCOSAL DISSECTION WITHOUT DISCONTINUATION OF ASPIRIN: STRAP STUDY (SAFE TREATMENT ON ANTIPLATELETS) (2014)
  • Author(s): Naohisa Yoshida
  • Organizer: United European Gastroenterology Week 2014
  • Place of Presentation: Austria Center Vienna
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] 消化管内視鏡検査における抗血栓薬内服下生検の安全性の検討 (2012)
  • Author(s): 小野敏嗣
  • Organizer: 第83回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
• [Remarks] 東京大学医学部附属病院消化器内科
  • URL: http://gastro.m.u-tokyo.ac.jp/
• [Remarks] 東京大学消化器内科消化管グループ
  • URL: http://www.todai-shoukakan.com/