Micro RNA expressions of chronic hepatitis related hepatocellular carcinoma
Project/Area Number |
24790686
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Kanazawa University |
Principal Investigator |
UEDA TERUYUKI 金沢大学, 医学系, 協力研究員 (80600741)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
Keywords | 肝細胞癌 / ウイルス性肝疾患 / 遺伝子発現解析 / 肝癌 / 遺伝子発現 |
Research Abstract |
DNA damage response genes in non-tumor lesions were associated with AP1 signaling which mediates the expression of many genes in CH-B-related HCC. In contrast, signal transducers and activators of transcription 1 and phosphatase and tensin homolog in non-tumor lesions were associated with early growth response protein 1 signaling that potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC. MicroRNAs were up- or down-regulated in cancerous tissue. These expression changes were confirmed as previously. Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma usinggraphical Gaussian modeling2013
Author(s)
Teruyuki Ueda, Masao Honda, Katsuhisa Horimoto, Sachiyo Aburatani, Shigeru Saito, Taro Yamashita, Yoshio Sakai, Mikiko Nakamura, Hajime Takatori, Hajime Sunagozaka, Shuichi Kaneko
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Journal Title
Genomics
Volume: 104(4)
Pages: 238-248
Related Report
Peer Reviewed
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[Journal Article] Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma usinggraphical Gaussian modeling.2013
Author(s)
Teruyuki Ueda, Masao Honda, Katsuhisa Horimoto, Sachiyo Aburatani, Shigeru Saito, Taro Yamashita, Yoshio Sakai, Mikiko Nakamura, Hajime Takatori, Hajime Sunagozaka, Shuichi Kaneko
-
Journal Title
Genomics
Volume: 104(4)
Pages: 238-248
Related Report
Peer Reviewed
-