Development of new endoscopic system using the composition imaging

• Project/Area Number: 24790691
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: HORIMATSU Takahiro 京都大学, 医学(系)研究科(研究院), 助教 (40511829)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 組成イメージング / 高感度近赤外光観察

Outline of Final Research Achievements

Using tissue imaging system with a near-infrared (NIR) spectrographic camera, normal tissue (non-cancerous part) and abnormal tissue (Cancer portion) was studied whether identifiable.Initially, we examined with 10 samples of early gastric cancer. The sensitivity and specificity were 60% and 80%, respectively. Then we examined with 18samples to assume that is increased. However, future increase of sensitivity and specificity were not observed.
As a major problem, the histopathology of cancer lesion often does not exhibit a uniform cell growth form.Macroscopic type and atypical degree of lesion would need to elucidate the differences.　Then, we additionally examined by the cultured cells.

Research Products

• [Journal Article] Next-Generation Narrow Band Imaging System for Colonic polyp Detection: A Prospective Multicenter Randomized Trial (2015)
  • Author(s): Takahiro Horimatsu, Yasushi Sano, Shinji Tanaka, Takuji Kawamura, Shoichi Saito, Mineo Iwatate, Shiro Oka, Koji Uno, Kenichi Yoshimura, Hideki Ishikawa, Manabu Muto, Hisao Tajiri
  • Journal Title: International Journal of Colorectal Disease Volume: in press
  • Peer Reviewed