• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a novel therapy for hepatic fibrosis using combination of partial splenic embolization and autologous bone marrow infusion

Research Project

Project/Area Number 24790704
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionYamaguchi University

Principal Investigator

ISHIKAWA Tsuyoshi  山口大学, 医学(系)研究科(研究院), 助教 (20569305)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肝線維化 / 門脈圧亢進症 / 自己骨髄細胞投与療法 / 部分的脾動脈塞栓術
Research Abstract

A new mouse model of partial splenic artery ligation (PSL) was originally developed and the procedure induced 67% of splenic infarction. Splenectomy (SP) or PSL was performed for cirrhotic mice induced by continuous intraperitoneal injection of carbon tetrachloride. Platelet counts were significantly increased by SP as compared to by PSL, but there were no statistical differences in other results between two procedures. Partial splenic embolization for cirrhotic human patients dramatically increased various growth factors such hepatocyte growth factor and some collagenases including matrix metalloproteinase, and similar results were shown in cirrhotic mice that underwent PSL. Near the future, we will clarify the synergistic effects on an improvement in hepatic fibrosis by combination of PSL and bone marrow cell infusion.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results)

  • [Journal Article] Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension2014

    • Author(s)
      Ishikawa T, Shiratsuki S, Matsuda T, Iwamoto T, Takami T, Uchida K, Terai S, Yamasaki T, Sakaida I
    • Journal Title

      J Gastroenterol.

      Volume: (掲載確定)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension.2014

    • Author(s)
      Ishikawa T, Shiratsuki S, Matsuda T, Iwamoto T, Takami T, Uchida K, Terai S, Yamasaki T, Sakaida I
    • Journal Title

      J Gastroenterol.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension2013

    • Author(s)
      Tsuyoshi Ishikawa, Takashi Matsuda, Takuya Iwamoto, Shuji Terai, Isao Sakaida
    • Organizer
      The 64th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      The Walter E. Washington Convention Center (Washington, DC. USA)
    • Year and Date
      2013-11-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] PSEが門脈圧亢進症を伴う肝硬変患者の血行動態に及ぼす影響2013

    • Author(s)
      石川剛、白築祥吾、松永一仁、松田崇史、岩本拓也、坂井田功
    • Organizer
      第20回日本門脈圧亢進症学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] PSEは門脈圧亢進症を伴う肝硬変患者に種々の有効性をもたらす。2013

    • Author(s)
      石川剛、白築祥吾、松永一仁、松田崇史、岩本拓也、坂井田功
    • Organizer
      第20回日本門脈圧亢進症学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] B-RTOは肝硬変患者の高インスリン血症・インスリン抵抗性を改善する。2013

    • Author(s)
      石川剛、松田崇史、岩本拓也、坂井田功
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] PSEによる血小板増加が肝再生・肝発癌・肝線維化に及ぼす影響2012

    • Author(s)
      石川剛、岩本拓也、坂井田功
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2012-10-10
    • Related Report
      2013 Final Research Report
  • [Presentation] B-RTOは肝硬変患者の高インスリン血症・インスリン抵抗性を改善する。

    • Author(s)
      石川 剛、松田 崇史、岩本 拓也、坂井田 功
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PSEが門脈圧亢進症を伴う肝硬変患者の血行動態に及ぼす影響

    • Author(s)
      石川 剛、白築 祥吾、松永 一仁、松田 崇史、岩本 拓也、坂井田 功
    • Organizer
      第20回日本門脈圧亢進症学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PSEは門脈圧亢進症を伴う肝硬変患者に種々の有効性をもたらす。

    • Author(s)
      石川 剛、白築 祥吾、松永 一仁、松田 崇史、岩本 拓也、坂井田 功
    • Organizer
      第20回日本門脈圧亢進症学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] C型肝硬変患者の門脈圧亢進症に対するPSEの有用性

    • Author(s)
      石川 剛
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      石川県立音楽堂(金沢市)
    • Related Report
      2012 Research-status Report
  • [Presentation] PSEは門脈圧亢進症を伴う肝硬変患者に種々の有効性をもたらす

    • Author(s)
      石川 剛
    • Organizer
      第19回日本門脈圧亢進症学会総会
    • Place of Presentation
      フォーシーズンズホテル椿山荘(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] PSEによる血小板増加が肝再生・肝発癌・肝線維化に及ぼす影響

    • Author(s)
      石川 剛
    • Organizer
      JDDW 2012
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi