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MicroRNA of the non-alcoholic steato-hepatitis

Research Project

Project/Area Number 24790706
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionKagawa University

Principal Investigator

TANI Joji  香川大学, 医学部附属病院, 助教 (00596075)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords非アルコール性脂肪肝炎 / miRNA / NASH / NAFLD / メトホルミン / マイクロRNA
Outline of Final Research Achievements

NASH increases year by year, and NASH becomes the non-viral liver cancer cause.
We analyzed those causes using microRNA and tried application to a diagnosis, treatment by identifying the cause micro RNA. Using the mouse of two kinds of non-alcoholic steato-hepatitis models, we extracted microRNA from the liver of the mouse and identified microRNA about extension. Also, we identified the microRNA which changed by giving metformin and galectin 9. We tried application in future by identifying microRNA with the serum of patients with non-alcoholic hepatitis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 Other

All Presentation (4 results)

  • [Presentation] メトホルミンによるNASHの進行抑制効果に関連するmiRNAの網羅的解析2014

    • Author(s)
      藤田浩二
    • Organizer
      第101回日本消化器病学会四国支部例会
    • Place of Presentation
      松山
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] メトホルミンの脂肪細胞に対する分化抑制機構を介したNASHの治療戦略―基礎的検討2014

    • Author(s)
      藤田浩二
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] NASHに対するメトホルミンの有効性、その効果に関連するマイクロRNAの同定

    • Author(s)
      桂明子
    • Organizer
      肝臓学会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] NASHに対するメトホルミンの有効性とその有効性に関連するマイクロRNAの同定

    • Author(s)
      桂明子
    • Organizer
      JDDW2013
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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