Factors that inhibit hepatocyte lipoapoptosis
| Project/Area Number |
24790709
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
AKAZAWA Yuko 長崎大学, 原爆後障害医療研究所, 助教 (80582113)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 脂肪酸 / アポトーシス / 飽和脂肪酸 / cIAP / DR5 / NASH / apoptosis / NAFLD / 小胞体ストレス / exendin 4 / cIAP-1 |
|---|
| Outline of Final Research Achievements |
Elevated serum free fatty acids and hepatocyte apoptosis are part of the features of nonalcoholic steatohepatitis (NASH). Cellular inhibitor of apoptosis (cIAP)-1 protein is an inhibitor of death receptor -mediated apoptosis. Aim of our study was to determine the role of cIAP-1 degradation during free fatty acid mediatedhepatocyte apoptosis.bcIAP-1 protein underwent degradation following treatment with palmitate in cultured HCC cells. SMAC mimetic JP1584, which induces rapid degradation of cIAP-1, significantly enhanced PA- mediated apoptosis in Mouse primary hepatocytes. However, JP 1584 did not sensitize primary hepatocytes from DR -/- mouse to apoptosis. These results indicated that degradation of cIAP-1 by PA enhances death receptor mediated pathway of lipoapoptosis. We are currently investigating the role of Troxerutin, a flavonoid, in FFA-mediated apoptosis. Troxerutin attenuated PA-mediated lipoapoptosis. We are currently investigating the mechanism that leads to this effect.
|
Report
(4 results)
Research Products
(12 results)
-
[Journal Article] Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis.2013
Author(s)
Akazawa Y Isomoto H, Matsushima K, Kanda T, Minami H, Yamaghchi N, Taura N, Shiozawa K, Ohnita K, Takeshima F, Nakano M, Moss J, Hirayama T, Nakao K.
-
Journal Title
PLOS one
Volume: 8(12)
Pages: 82322-82322
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
