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Investigation of genetic alterations of mucin-depleted foci in patients with sporadic colorectal cancer

Research Project

Project/Area Number 24790713
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionYokohama City University

Principal Investigator

SAKAI Eiji  横浜市立大学, 附属病院, 指導診療医 (30600233)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsMDF / 前がん病変 / 大腸発癌 / ACF / 遺伝子変異 / メチル化異常 / mucin-depleted foci / de novo pathway / 大腸発がん / DNAメチル化
Research Abstract

Mucin-depleted foci (MDF), formed by dysplastic crypts devoid of mucin production have been recognized to be correlated with colorectal carcinogenesis and to serve as preneoplastic lesions of colorectal cancer (CRC). In the present study, we investigated the genetic and epigenetic alterations of MDF to reveal carcinogenic mechanisms of these lesions. A part of MDF showed aberrant beta-catenin accumulation as well as flat-neoplasms, suggesting that these lesions might be served as precursor of CRC which develop through de novo pathway. However, we could not analyze detail genetic and epigenetic alterations, because of low quality and quantity of DNA. In the future, endoscopic detection may be help to reveal carcinogenic mechanisms of MDF development.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Methylation epigenotypes and genetic features in colorectal laterally spreading tumors2014

    • Author(s)
      Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A.
    • Journal Title

      Int J Cancer

      Volume: in press Issue: 7 Pages: 1586-95

    • DOI

      10.1002/ijc.28814

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accumulation of aberrant DNA methylation during colorectal cancer development2014

    • Author(s)
      Sakai E, Nakajima A, Kaneda A.
    • Journal Title

      World J Gastroenterol

      Volume: 28; 20(4) Issue: 4 Pages: 978-87

    • DOI

      10.3748/wjg.v20.i4.978

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation epigenotypes and genetic features in colorectal laterally spreading tumors.2014

    • Author(s)
      Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A.
    • Journal Title

      Int J Cancer.

      Volume: in print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of aberrant DNA methylation during colorectal cancer development.2014

    • Author(s)
      Sakai E, Nakajima A, Kaneda A.
    • Journal Title

      World J Gastroenterol.

      Volume: 28 (20) Pages: 978-87

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] The characteristics of genetic and epigenetic alterations in laterally spreading colorectal tumors.2013

    • Author(s)
      Sakai E, Ohata K, Chiba H, Matsuhashi N, Fukushima J, Endo H, Takahashi H, Aburatani H, Nakajima A, Kaneda A.
    • Organizer
      UEGW annual meeting
    • Place of Presentation
      ICC Berlin
    • Year and Date
      2013-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] The genetic alterations and unique epigenotype of laterally spreading colorectal tumors2013

    • Author(s)
      Sakai E, Ohata K, Chiba H, Matsuhashi N, Fukushima J, Endo H, Takahashi H, Aburatani H, Nakajima A, Kaneda A.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(口演発表)
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] The characteristics of genetic and epigenetic alterations in laterally spreading colorectal tumors.2013

    • Author(s)
      Sakai E, Ohata K, Chiba H, Matsuhashi N, Fukushima J, Endo H, Takahashi H, Aburatani H, Nakajima A, Kaneda A.
    • Organizer
      UEGW annual meeting
    • Place of Presentation
      ドイツ ベルリン
    • Related Report
      2013 Annual Research Report
  • [Presentation] The genetic alterations and unique epigenotype of laterally spreading colorectal tumors.2013

    • Author(s)
      Sakai E, Ohata K, Chiba H, Matsuhashi N, Fukushima J, Endo H, Takahashi H, Aburatani H, Nakajima A, Kaneda A.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Low dose resveratrol do not inhibit colorectal tumor initiation but progression via suppression of STAT3 signal2012

    • Author(s)
      酒井英嗣
    • Organizer
      第71回 日本癌学会
    • Place of Presentation
      ホテルロイトン札幌(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] The histopathological characteristics of mucin-depleted foci in patients with sporadic colorectal cancer.2012

    • Author(s)
      Eiji Sakai
    • Organizer
      AACR annual meeting 2012
    • Place of Presentation
      Chikago, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Capsule endoscopy with flexible spectral imaging color enhancement reduces the bile-pigments effect and improves the detectability of small bowel lesions.2012

    • Author(s)
      Eiji Sakai
    • Organizer
      DDW 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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