| Project/Area Number |
24790713
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
SAKAI Eiji 横浜市立大学, 附属病院, 指導診療医 (30600233)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MDF / 前がん病変 / 大腸発癌 / ACF / 遺伝子変異 / メチル化異常 / mucin-depleted foci / de novo pathway / 大腸発がん / DNAメチル化 |
|---|
| Research Abstract |
Mucin-depleted foci (MDF), formed by dysplastic crypts devoid of mucin production have been recognized to be correlated with colorectal carcinogenesis and to serve as preneoplastic lesions of colorectal cancer (CRC). In the present study, we investigated the genetic and epigenetic alterations of MDF to reveal carcinogenic mechanisms of these lesions. A part of MDF showed aberrant beta-catenin accumulation as well as flat-neoplasms, suggesting that these lesions might be served as precursor of CRC which develop through de novo pathway. However, we could not analyze detail genetic and epigenetic alterations, because of low quality and quantity of DNA. In the future, endoscopic detection may be help to reveal carcinogenic mechanisms of MDF development.
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