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Immunogenic death of cells treated with new photodynamic therapy (PDT) with glucose-conjugated chlorin (G-chlorin)

Research Project

Project/Area Number 24790717
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionNagoya City University

Principal Investigator

TANAKA MAMORU  名古屋市立大学, 医学(系)研究科(研究院), 臨床研究医 (80617861)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsPDT / Calreticulin / HMGB1 / 腫瘍免疫増強効果
Outline of Final Research Achievements

Both the pre-apoptotic exposure to calreticulin (CRT) and the post-apoptotic release of high-mobility group box 1 protein (HMGB1) are required for immunogenic cell death. Photodynamic therapy (PDT) uses non-toxic photosensitizers and visible light at a specific wavelength in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature, and stimulate the host immune system. We have previously shown that glucose-conjugated chlorin (G-chlorin) had superior cancer cell selectivity, and it effectively suppressed the growth of xenograft tumors. In this study, we evaluated the immunogenicity of PDT with G-chlorin treatment in colon cancer cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) Book (1 results)

  • [Journal Article] A novel photodynamic therapy targeting cancer cells and tumor-associated macrophages.2015

    • Author(s)
      Hayashi N, Kataoka H, Yano S, Tanaka M, Moriwaki K, Akashi H, Suzuki S, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T.
    • Journal Title

      Mol Cancer Ther.

      Volume: 2 Issue: 4 Pages: 452-60

    • DOI

      10.1158/1535-7163.mct-13-0393

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin.2014

    • Author(s)
      Tanaka M, Kataoka H, Yano S, Ohi H, Moriwaki K, Akashi H, Taguchi T, Hayashi N, Hamano S, Mori Y, Kubota E, Tanida S, Joh T.
    • Journal Title

      Mol Cancer Ther.

      Volume: 4 Issue: 2 Pages: 767-75

    • DOI

      10.1158/1535-7163.mct-14-0348

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 新規光感受性物質である糖鎖連結クロリンによる抗腫瘍免疫増強メカニズムの検討2014

    • Author(s)
      田中  守,片岡 洋望,溝下  勤,森  義徳,久保田英嗣,矢野 重信,城  卓志
    • Organizer
      第25回 日本消化器癌発生学会総会
    • Place of Presentation
      ホテル日航福岡 (福岡県・福岡市)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 消化管癌に対する新規光療法における抗腫瘍免疫増強メカニズムの検討2014

    • Author(s)
      田中 守 片岡洋望 林 則之 片野敬仁 西脇裕高 濱野真吾 尾関啓司 塚本宏延 海老正秀 溝下 勤 澤田 武 森 義徳 久保田英嗣 谷田諭史 矢野重信 城 卓志
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム (東京都)
    • Year and Date
      2014-05-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「消化管癌に対する次世代PDTの現状と展望」2013

    • Author(s)
      田中 守 片岡洋望 林 則之 片野敬仁 西脇裕高 濱野真吾 尾関啓司 塚本宏延 海老正秀 溝下 勤 澤田 武 森 義徳 久保田英嗣 谷田諭史 矢野重信 城 卓志
    • Organizer
      第45 回胃病態機能研究会
    • Place of Presentation
      名古屋市立大学 (名古屋)
    • Related Report
      2013 Research-status Report
  • [Presentation] GISTに対する糖鎖結光感受性物質を用いた新規光線力学的治療効果の基礎的検討2013

    • Author(s)
      田中  守、片岡 洋望、濱野 真吾、溝下  勤、
    • Organizer
      第24回日本消化器癌発生学会
    • Place of Presentation
      石川県立音楽堂 (金沢)
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖鎖連結クロリンによる新規光線力学的治療の腫瘍免疫増強効果2013

    • Author(s)
      Mamoru Tanaka, Hiromi Kataoka, Shingo Hamano, Masahide Ebi, Tsutomu Mizoshita, Yoshinori Mori, Eiji Kubota, Shigenobu Yano and Takashi Joh
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] ANTITUMOR EFFECTS OF NOVEL PHOTODYNAMIC THERAPY WITH GLUCOSE CONJUGATED CHLORIN FOR GIST2013

    • Author(s)
      M. Tanaka, H. Kataoka, S. Yano, T. Joh
    • Organizer
      21st United European Gastroenterology Week
    • Place of Presentation
      ICC (ベルリン,ドイツ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Immunogenic death of cells treated with new photodynamic therapy (PDT) with glucose conjugated chlorin (G-chlorin)2013

    • Author(s)
      M. Tanaka, H. Kataoka, E. Kubota, T. Joh
    • Organizer
      12th International Congress On Targeted Anticancer Therapies 2014 (TAT 2014)
    • Place of Presentation
      the Capital Hilton Hotel in Washington (ワシントン,アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Novel photodynamic therapy with glucose conjugated chlorine for GIST2013

    • Author(s)
      M. Tanaka, H. Kataoka, S. Yano, T. Joh
    • Organizer
      The 17th Biennial Meeting of Society for Free Radical Research International
    • Place of Presentation
      京都国際会議場(京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Antitumor effects of novel photodynamic therapy with glucose conjugated chlorine for GIST2012

    • Author(s)
      田中 守、片岡 洋望、城 卓志
    • Organizer
      第71回日本癌学会 学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] GISTに対するグルコース連結光感受性物質を用いた新規光線力学的治療の基礎的検討2012

    • Author(s)
      田中 守、片岡 洋望、城 卓志
    • Organizer
      第20回 日本消化器関連学会週間(JDDW2012 KOBE)
    • Place of Presentation
      神戸国際展示場、ポートピアホテル、神戸国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Book] Progress in Medicine2013

    • Author(s)
      田中 守
    • Total Pages
      3
    • Publisher
      株式会社 ライフ・サイエンス
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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