Immunogenic death of cells treated with new photodynamic therapy (PDT) with glucose-conjugated chlorin (G-chlorin)
Project/Area Number |
24790717
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Nagoya City University |
Principal Investigator |
TANAKA MAMORU 名古屋市立大学, 医学(系)研究科(研究院), 臨床研究医 (80617861)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | PDT / Calreticulin / HMGB1 / 腫瘍免疫増強効果 |
Outline of Final Research Achievements |
Both the pre-apoptotic exposure to calreticulin (CRT) and the post-apoptotic release of high-mobility group box 1 protein (HMGB1) are required for immunogenic cell death. Photodynamic therapy (PDT) uses non-toxic photosensitizers and visible light at a specific wavelength in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature, and stimulate the host immune system. We have previously shown that glucose-conjugated chlorin (G-chlorin) had superior cancer cell selectivity, and it effectively suppressed the growth of xenograft tumors. In this study, we evaluated the immunogenicity of PDT with G-chlorin treatment in colon cancer cells.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] A novel photodynamic therapy targeting cancer cells and tumor-associated macrophages.2015
Author(s)
Hayashi N, Kataoka H, Yano S, Tanaka M, Moriwaki K, Akashi H, Suzuki S, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T.
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Journal Title
Mol Cancer Ther.
Volume: 2
Issue: 4
Pages: 452-60
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin.2014
Author(s)
Tanaka M, Kataoka H, Yano S, Ohi H, Moriwaki K, Akashi H, Taguchi T, Hayashi N, Hamano S, Mori Y, Kubota E, Tanida S, Joh T.
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Journal Title
Mol Cancer Ther.
Volume: 4
Issue: 2
Pages: 767-75
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 糖鎖連結クロリンによる新規光線力学的治療の腫瘍免疫増強効果2013
Author(s)
Mamoru Tanaka, Hiromi Kataoka, Shingo Hamano, Masahide Ebi, Tsutomu Mizoshita, Yoshinori Mori, Eiji Kubota, Shigenobu Yano and Takashi Joh
Organizer
第72回日本癌学会学術総会
Place of Presentation
パシフィコ横浜 (横浜)
Related Report
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