| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Peripheral HCV specific CD8 T cells in patients with chronic HCV infections showed higher expressions of suppressive co-stimulation molecules such as PD-1, CTLA4, and LAG-3 compared with EBV or influenza specific CD8 T cells from the same individuals. HCV specific CD8 T cells in patients with higher viral load tended to express multiple suppressive co-stimulation molecules. Of interest, PD-1 positive HCV specific CD8 T cells produced higher TNFα and lower IL-10 compared with PD-1 negative subsets. There results suggest that HCV specific CD 8 T cells fall to be dysfunctional via the expression of multiple suppressive co-stimulation molecules during persistent HCV infection. Further study is needed to clarify the mechanism behind the immune tolerance in the liver and to overcome the HCV infection in humans.
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