New biomarkers of primary biliary cirrhosis
| Project/Area Number |
24790724
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | PBC / TGF-b / Smad / TGF-β |
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| Outline of Final Research Achievements |
Chronic liver inflammation and hepatic regeneration induced by host cellular immune responses can increase the risk of HCC development. To investigate the mechanisms of fibrocarcinogenesis in PBC, we studied 45 PBC not developing HCC (Stage I: 16, II:13, III:13, IV:3) and 6 PBC developing HCC. We performed inmmunohistochemical analysis using our phospho-Smad3 antibodies. As PBC livers progressed from chronic hepatitis through cirrhosis to HCC, hepatocytic linker phosphorylated Smad3 (pSmad3L) increased with fibrotic stage and C-terminal phosphorylated Smad3 (pSmad3C) decreased. We conclude chronic inflammation contributes directly to fibrocarcinogenesis by shifting hepatocytic Smad3-mediated signaling from tumor suppression to oncogenesis both in PBC. These data also suggest pSmad3L can be new biomarker for HCC and high pSmad3L group need careful surveillance for early detection of HCC.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C.2013
Author(s)
Yamaguchi T, Matsuzaki K, Inokuchi R, Kawamura R, Yoshida K, Murata M, Fujisawa J, Fukushima N, Sata M, Kage M, Nakashima O, Tamori A, Kawada N, Tsuneyama K, et al.
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Journal Title
Hepatol Res.
Volume: (In press)
Issue: 12
Pages: 1327-42
DOI
Related Report
Peer Reviewed
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[Journal Article] Possible Involvement of Foxp3(+) Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid.2013
Author(s)
Koyabu M, Uchida K, Sakaguchi Y, Fukata N, Kusuda T, Miyoshi H, Yoshida K, Sumimoto K, Mitsuyama T, Fukui T, Nishio A, Okazaki K.
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Journal Title
Int J Rheumatol.
Volume: 2013
Pages: 367325-30
DOI
Related Report
Peer Reviewed
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[Presentation] SVRに至ったC型慢性肝炎症例の組織学的検討2014
Author(s)
村田美樹, 松崎恒一, 吉田勝紀, 山口隆志, 井口亮輔, 川村梨那子,関 寿人, 岡崎和一
Organizer
第50回日本肝臓学会総会
Place of Presentation
ホテルニューオータニ（東京）
Year and Date
2014-05-29 – 2014-05-30
Related Report
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[Presentation] IgG4関連疾患よりみた自験自己免疫性肝疾患の検討2013
Author(s)
吉田勝紀, 小藪雅紀, 内田一茂, 池田広記, 中橋佳嗣, 廣原淳子, 山口隆志, 松崎恒一, 村田美樹, 関寿人, 岡崎和一
Organizer
第４９回日本肝臓学会総会
Place of Presentation
東京 京王プラザホテル
Related Report
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[Presentation] 単クローン抗体を用いたＥＬＩＳＡによるリン酸化Smad定量化の試み（癌・線維化シグナルからみたＣ型慢性肝疾患の病態把握）2013
Author(s)
山口隆志, 松崎恒一, 吉田勝紀, 村田美樹, 井口亮輔, 川村梨那子, 関寿人, 岡崎和一, 横井川規巨, 柳田英佐, 北出浩章, 權雅憲
Organizer
第４９回日本肝臓学会総会
Place of Presentation
東京 京王プラザホテル
Related Report
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[Presentation] Reversible or irreversible phospho-Smad3 signaling between tumor-suppression and fibro-carcinogenesis in hepatitis C virus-related chronic liver diseases2012
Author(s)
Yoshida K, Yamaguchi T, Murata M, Inokuchi R, Kawamura R, Fukushima N, Sata M, Kage M, Nakashima O, Tamori A, Kawada N, Tsuneyama K, Okazaki K, Seki T, and Matsuzaki K
Organizer
The 10th JSH Single Topic Conference
Place of Presentation
京王プラザホテル（東京）
Related Report
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[Presentation] Reversible or irreversible phospho-Smad2/3 signaling between tumor-suppression and fibro-carcinogenesis in hepatitis C virus-related chronic liver diseases2012
Author(s)
Murata M, Yamaguchi T, Inokuchi R, Yoshida K, Kawamura R, Fukushima N, Sata M, Masayoshi Kage M, Nakashima O, Tamori A, Kawada N, Tsuneyama K, Okazaki K, Seki T, and Matsuzaki K
Organizer
The 2nd International symposium by JSPS core-to-core program "Cooperative international framework in TGF-β family signaling"
Place of Presentation
昭和薬科大学（東京）
Related Report
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