| Project/Area Number |
24790732
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOKAWA Hiroaki 東北大学, 大学院医学系研究科, 教授 (00235681)
YASUDA Satoshi 国立循環器病研究センター, 病院, 部門長 (00431578)
NISHIMIYA Kensuke 東北大学, 東北メディカルメガバンク機構, 非常勤講師 (10734238)
MATSUMOTO Yasuharu 東北大学, 大学病院, 助教 (90600528)
TAKAHASHI Jun 東北大学, 大学病院, 講師 (00375081)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 薬剤溶出ステント / 異常血管反応 / Vaso vasorum / 冠攣縮 / Vaso Vasorum / 冠動脈疾患 / 薬剤溶出性ステント / 血管過収縮反応 / Rhoキナーゼ / 循環器 |
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| Outline of Final Research Achievements |
We evaluated a vamotion in new generation drug-eluting stent (DES) implantation, everolimus-eluting stent (EES) and biolimus-eluting stent. The BES could improve an abnormal vasomotion compared with first generation DES and EES. In immunohistological analysis, enhanced inflammatory response and adventitial Vasa Vasorum (VV) formation, which were observed in first generation DES, was significantly inhibited in BES site. Furthermore, we succeeded VV imaging in vivo by optical frequency domain imaging in pigs and even in humans.
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