• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Impact of new generation drug-eluting stent on coronary vasomotion

Research Project

Project/Area Number 24790732
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionTohoku University

Principal Investigator

TSUBURAYA Ryuji  東北大学, 大学病院, 助教 (30599882)

Co-Investigator(Renkei-kenkyūsha) SHIMOKAWA Hiroaki  東北大学, 大学院医学系研究科, 教授 (00235681)
YASUDA Satoshi  国立循環器病研究センター, 病院, 部門長 (00431578)
NISHIMIYA Kensuke  東北大学, 東北メディカルメガバンク機構, 非常勤講師 (10734238)
MATSUMOTO Yasuharu  東北大学, 大学病院, 助教 (90600528)
TAKAHASHI Jun  東北大学, 大学病院, 講師 (00375081)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords薬剤溶出ステント / 異常血管反応 / Vaso vasorum / 冠攣縮 / Vaso Vasorum / 冠動脈疾患 / 薬剤溶出性ステント / 血管過収縮反応 / Rhoキナーゼ / 循環器
Outline of Final Research Achievements

We evaluated a vamotion in new generation drug-eluting stent (DES) implantation, everolimus-eluting stent (EES) and biolimus-eluting stent. The BES could improve an abnormal vasomotion compared with first generation DES and EES. In immunohistological analysis, enhanced inflammatory response and adventitial Vasa Vasorum (VV) formation, which were observed in first generation DES, was significantly inhibited in BES site. Furthermore, we succeeded VV imaging in vivo by optical frequency domain imaging in pigs and even in humans.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Invited: 1 results)

  • [Journal Article] Accuracy of Optical Frequency Domain Imaging for Evaluation of Coronary Adventitial Vasa Vasorum Formation After Stent Implantation in Pigs and Humans - A Validation Study.2015

    • Author(s)
      Nishimiya K, Matsumoto Y, Uzuka H, Oyama K, Tanaka A, Taruya A, Ogata T, Hirano M, Shindo T, Hanawa K, Hasebe Y, Hao K, Tsuburaya R, Takahashi J, Miyata S, Ito K, Akasaka T, Shimokawa H
    • Journal Title

      Circulation Journal

      Volume: E pub

    • NAID

      130005073155

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Enhanced adventitial vasa vasorum formation in patients with vasospastic angina -Assessment with optical frequency domain imaging-2014

    • Author(s)
      Nishimiya K, Matsumoto Y, Takahashi J, Kato T, Oyama K, Uzuka H, Odaka Y, Nihei T, Hao K, Tsuburaya R, Ito K, Shimokawa H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Enhanced adventitial vasa vasorum formation in patients with vasospastic angina - Assessment with optical frequency domain imaging-2014

    • Author(s)
      Nishimiya K, Matsumoto Y, Takahashi J, Kato T, Odaka Y, Nihei T, Hao K, Tsuburaya R, Ito K, Shimokawa H.
    • Organizer
      European Society Congress 2014
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Important Role of Adventitial Vasa Vasorum in the Pathogensis of Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs in Vivo2013

    • Author(s)
      Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Tomohiko Shindo, Kenichiro Hanawa, Yuhi Hasebe, Ryuji Tsuburaya, Takashi Shiroto, Kenta Ito, Hatsue Ishibashi-Ueda, Satoshi Yasuda, and Hiroaki Shimokawa
    • Organizer
      ESC Congress 2013
    • Place of Presentation
      Amsterdam, Nederland
    • Related Report
      2013 Research-status Report
  • [Presentation] Important Role of Adventitial Vasa Vasorum in the Pathogensis of Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs in Vivo2013

    • Author(s)
      Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Tomohiko Shindo, Kenichiro Hanawa, Yuhi Hasebe, Ryuji Tsuburaya, Takashi Shiroto, Kenta Ito, Hatsue Ishibashi-Ueda, Satoshi Yasuda, and Hiroaki Shimokawa
    • Organizer
      American heart association scientific session 2013
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] New generation biolimus A9-eluting stent suppresses coronary hyperconstricting responses after stent implantation through Rho-kinase pathway inhibition in pigs in vivo2013

    • Author(s)
      西宮 健介
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 薬剤溶出性ステント留置後の冠攣縮性狭心症 ~From bench to bedside~2013

    • Author(s)
      圓谷 隆治
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] New generation biolimus A9-eluting stent suppresses coronary hyperconstricting responses and inflammation through Rho-kinase pathway inhibition in pigs -comparison with a Sirolimus-Eluting Stent-2012

    • Author(s)
      西宮 健介
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      ドイツ、ミュンヘン
    • Related Report
      2012 Research-status Report
  • [Presentation] Beneficial Effects of Polymer-Free Biolimus-Eluting Stents on Coronary Vasomotion in Pigs in Vivo -Possible Involvement of Rho-kinase Inhibition-2012

    • Author(s)
      西宮 健介
    • Organizer
      AHA Scinetific Session
    • Place of Presentation
      アメリカ、ロサンゼルス
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi