| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Although pluripotent stem cell-derived cardiomyocytes are a promising tool for cardiac repair following cardiac injury, more study is required to improve the cell engraftment. We tested our novel 3D-culture system for the transplantation of stem cell-derived cardiomyocytes for not only graft cell survival but also electrical integration.
The 3D-culured human iPSC-cardiomyocytes survived following transplantation in injured guinea pig hearts, but they did not couple with host cardiomyocytes by fluorescent Ca sensor GCaMP3 imaging system. Additional study is needed to improve the host-graft electrical integration.
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