| Project/Area Number |
24790751
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | オートファジー / リモデリング / 心筋梗塞 / 心不全 / レスベラトロール / 心保護 / 心保護効果 |
|---|
| Research Abstract |
Autophagy compensate the lack of energy in cardiomyocyte suffering from acute or old myocardial infarction. However there is no clinical therapeutic approach via cardiac autophagy yet. Then we investigated the effect of resveratrol, a popular natural polyhenolic compound with antioxidant and proautophagic actions, on postinfarction heart failure using mouse myocardial infarction model. Resveratrol reversed left ventricular dilatation (reverse remodeling) and significantly improved cardiac dysfunction. Autophagy was augmented in those heart as shown autophagy related protein expression and ultrastructure findings including autophagic vacuoles. Resveratrol enhanced the activity of AMPK and suppressed the activity of mTOR and p70S6 kinese. Myocardial ATP production was increased in those heart. In conclusion, resveratrol is a beneficial pharmacological tool that augments autophagy to bring about reverse remodeling in the post infarction heart.
|
