| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Genome-wide association study (GWAS) for atrial fibrillation (AF) has identified AF susceptibility loci. The purpose of our study was to clarify the cumulative effects of 10 GWAS-proven single nucleotide polymorphisms (SNPs) in AF patients with heart failure (HF). In addition, we examined the associations of these SNPs in two clinical forms of HF. 278 Japanese patients diagnosed with HF were enrolled. Mean GRS in patients of AF was significantly higher than that of patients without AF. Additionally, HCN4 gene might play an inverse role in pathogenesis of AF between the two clinical forms of HF (HF with preserved and impaired left ventricular systolic function). We found that the GRS based on 10 GWAS-proven SNPs for AF was significantly associated with AF in patients with HF.
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