Coronary Plaque Tissue Component in Patients with Vasospastic Angina
Project/Area Number |
24790769
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kumamoto University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 冠攣縮 / 血管内超音波 / 冠動脈プラーク / 組織性状 |
Research Abstract |
1. In patients with vasospastic angina (VSA), which was considered as manifestation of early coronary atherosclerotic change, diffuse intimal thickening was observed by intravascular ultrasound (IVUS) imaging compared with normal control subjects. However, tissue component of the diffuse coronary plaque was consisted of predominantly stable fibrous tissue rather than unstable necrotic tissue in patients with VSA. Also, regarding cardiovascular (CV) outcomes, CV events was rarely observed with favorable prognosis. 2. Serial IVUS showed that optimal medical therapy (OMT) could minimize the progression of the coronary atherosclerosis in patients with VSA. 3. Although our prior study demonstrated that endothelial function was impaired in patients with VSA than in normal control subjects, OMT could improve the endothelial dysfunction.
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Report
(3 results)
Research Products
(71 results)
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[Journal Article] Lack of association between peri-procedural myocardial damage and CYP2C19 gene variant in elective percutaneous coronary intervention2014
Author(s)
Yoshimura H, Kaikita K, Ono T, Iwashita S, Nakayama N, Sato K, Horio E, Tsujita K, Kojima S, Tayama S, Hokimoto S, Ogawa H.
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[Journal Article] Correlation Between Extent of Myocardial Fibrosis Assessed by Cardiac Magnetic Resonance and Cardiac Troponin T Release in Patients With Nonischemic Heart Failure2014
Author(s)
Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda 0, Yamashita Y, Ogawa H
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Am J Cardiol
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[Journal Article] Serial intravascular ultrasound assessment of very late stent thrombosis after sirolimus-eluting stent placement2014
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Yamanaga K, Tsujita K, Shimomura H, Nakamura Y, Ogura Y, Onoue Y, Chazono N, Nagata T, Morisaki S, Kudo T, Yamada Y, Komura N, Miyazaki T, Akasaka T, Horio E, Sato K, Arima Y, Kojima S, Kaikita K, Tayama S, Hokimoto S, Ogawa H
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J Cardiol
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[Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts outcome of heart failure with reduced ejection fraction2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H
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Journal Title
Circ J
Volume: 78
Pages: 903-910
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[Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction2014
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Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H
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Can J Cardiol
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Pages: 338-344
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[Journal Article] Comprehensive analysis of intravascular ultrasound and angiographic morphology of culprit lesions between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome2014
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Takaoka N, Tsujita K, Kaikita K, Hokimoto S, Mizobe M, Nagano M, Horio E, Sato K, Nakayama N, Yoshimura H, Yamanaga K, Komura N, Kojima S, Tayama S, Nakamura S, Ogawa H
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Int J Cardiol
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[Journal Article] Impact of CYP2C19 polymorphism on platelet function tests and coagulation and inflammatory biomarkers in patients undergoing percutaneous coronary intervention2014
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Kaikita K, Ono T, Iwashita S, Nakayama N, Sato K, Horio E, Nakamura S, Tsujita K, Tayama S, Hokimoto S, Sakamoto T, Nakao K, Oshima S, Sugiyama S, Ogawa H
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J Atheroscler Thromb
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Pages: 64-76
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[Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts2014
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Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H
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Journal Title
Heart Vessels
Volume: 29
Pages: 231-237
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[Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts.2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
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Journal Title
Heart Vessels.
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Issue: 2
Pages: 231-237
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[Journal Article] Intravascular ultrasound morphology of culprit lesions and clinical demographics in patients with acute coronary syndrome in relation to low-density lipoprotein cholesterol levels at onset.2014
Author(s)
Takaoka N, Tsujita K, Kaikita K, Hokimoto S, Yamanaga K, Komura N, Chitose T, Ono T, Mizobe M, Horio E, Sato K, Nakayama N, Saito M, Iwashita S, Kojima S, Tayama S, Sugiyama S, Nakamura S, Ogawa H.
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Journal Title
Heart Vessels
Volume: in press
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[Journal Article] Impact of CYP2C19 polymorphism on platelet function tests and coagulation and inflammatory biomarkers in patients undergoing percutaneous coronary intervention.2014
Author(s)
Kaikita K, Ono T, Iwashita S, Nakayama N, Sato K, Horio E, Nakamura S, Tsujita K, Tayama S, Hokimoto S, Sakamoto T, Nakao K, Oshima S, Sugiyama S, Ogawa H.
-
Journal Title
J Atheroscler Thromb
Volume: 21
Pages: 64-76
NAID
Related Report
Peer Reviewed
-
[Journal Article] Comprehensive analysis of intravascular ultrasound and angiographic morphology of culprit lesions between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome.2014
Author(s)
Takaoka N, Tsujita K, Kaikita K, Hokimoto S, Mizobe M, Nagano M, Horio E, Sato K, Nakayama N, Yoshimura H, Yamanaga K, Komura N, Kojima S, Tayama S, Nakamura S, Ogawa H.
-
Journal Title
Int J Cardiol.
Volume: 171
Issue: 3
Pages: 423-430
DOI
Related Report
Peer Reviewed
-
[Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction.2014
Author(s)
Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
-
Journal Title
Can J Cardiol.
Volume: 30
Issue: 3
Pages: 338-344
DOI
Related Report
Peer Reviewed
-
[Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts outcome of heart failure with reduced ejection fraction.2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
-
Journal Title
Circ J
Volume: 78
Pages: 903-910
NAID
Related Report
Peer Reviewed
-
[Journal Article] Serial intravascular ultrasound assessment of very late stent thrombosis after sirolimus-eluting stent placement.2014
Author(s)
Yamanaga K, Tsujita K, Shimomura H, Nakamura Y, Ogura Y, Onoue Y, Chazono N, Nagata T, Morisaki S, Kudo T, Yamada Y, Komura N, Miyazaki T, Akasaka T, Horio E, Sato K, Arima Y, Kojima S, Kaikita K, Tayama S, Hokimoto S, Ogawa H.
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Journal Title
J Cardiol
Volume: in press
Related Report
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-
[Journal Article] Correlation Between Extent of Myocardial Fibrosis Assessed by Cardiac Magnetic Resonance and Cardiac Troponin T Release in Patients With Nonischemic Heart Failure.2014
Author(s)
Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
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Am J Cardiol
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[Journal Article] Intravascular ultrasound morphology of culprit lesions and clinical demographics in patients with acute coronary syndrome in relation to low-density lipoprotein cholesterol levels at onset2013
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Takaoka N, Tsujita K, Kaikita K, Hokimoto S, Yamanaga K, Komura N, Chitose T, Ono T, Mizobe M, Horio E, Sato K, Nakayama N, Saito M, Iwashita S, Kojima S, Tayama S, Sugiyama S, Nakamura S, Ogawa H
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[Journal Article] Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm : analysis of a single-center study over 20 years2013
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Sato K, Kaikita K, Nakayama N, Horio E, Yoshimura H, Ono T, Ohba K, Tsujita K, Kojima S, Tayama S, Hokimoto S, Matsui K, Sugiyama S, Yamabe H, Ogawa H
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[Journal Article] Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure.2013
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Takashio S, Yamamuro M, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
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J Am Coll Cardiol.
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[Journal Article] Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years.2013
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Sato K, Kaikita K, Nakayama N, Horio E, Yoshimura H, Ono T, Ohba K, Tsujita K, Kojima S, Tayama S, Hokimoto S, Matsui K, Sugiyama S, Yamabe H, Ogawa H.
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[Journal Article] Coronary plaque component in patients with vasospastic angina: a virtual histology intravascular ultrasound study.2013
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Tsujita K, Sakamoto K, Kojima S, Kojima S, Takaoka N, Nagayoshi Y, Sakamoto T, Tayama S, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Nakamura S, Ogawa H.
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Int J Cardiol.
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Issue: 3
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[Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts.2013
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H
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[Journal Article] A survival case of cardiogenic shock due to left main coronary artery myocardial infarction: successful cooperation with on-site percutaneous coronary intervention and helicopter emergency medical service.2012
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Journal Title
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[Journal Article] Multidisciplinary mechanical supports improve outcome in a shock patient with cardiac amyloidosis: a case report.2012
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[Journal Article] Management of intra-aortic balloon counterpulsation by argatroban anticoagulation in a patient with a history of heparin-induced thrombocytopenia.2012
Author(s)
Tabata N, Tsujita K, Mizobe M, Hirakawa K, Tanaka T, Yamamuro M, Yamamoto E, Kaikita K, Tayama S, Hokimoto S, Sugiyama S, Ogawa H
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[Presentation] Tissue Dopplar-derived E/e' Ratio at Stent Implantation is a Powerful Predictor of In-Stent Restenosis in Patients with Coronary Artery Disease2014
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Komura N, Tsujita K, Yamanaga K, Kaikita K, Hokimoto S, Iwashita S, Miyazaki T, Akasaka T, Sato K, Horio E, Yoshimura H, Arima Y, Kojima S, Tayama S, Nakamura S, Sugiyama S, Hibi K, Kimura K, Uemura S, Ogawa H
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62th American College of Cardiology Scientific Sessions
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[Presentation] Impaired Peripheral Endothelial Function as Assessed by Digital Reactive Hyperemia Peripheral Arterial Tonometry and Risk of In-Stent Restenosis2014
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86th American Heart Association Scientific Sessions
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86th American Heart Association Scientific Sessions
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[Presentation] Impact of Acetylcholine-provoked Diffuse Coronary Spasm on Clinical Features and Long-term Prognosis of Patients With Coronary Spasm2013
Author(s)
Sato K, Kaikita K, Yoshimura H, Nakayama N, Horio E, Ohba K, Tsujita K, Tayama S, Hokimoto S, Matsui K, Sugiyama S, Yamabe H, Ogawa H
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86th American Heart Association Scientific Sessions
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[Presentation] Single-Wire Pressure and Flow Velocity Measurement to Quantify Microvascular Dysfunction in Patients With Coronary Vasospastic Angina2013
Author(s)
Yamanaga K, Tsujita K, Komura N, Kaikita K, Hokimoto S, Miyazaki T, Saito M, Akasaka T, Sato K, Horio E, Yoshimura H, Arima Y, Kojima S, Tayama S, Nakamura S, Ogawa H
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Related Report
-
-
[Presentation] Impaired Peripheral Endothelial Function as Assessed by Digital Reactive Hyperemia Peripheral Arterial Tonometry and Risk of In-Stent Restenosis2013
Author(s)
Komura N, Tsujita K, Yamanaga K, Kaikita K, Hokimoto S, Iwashita S, Miyazaki T, Akasaka T, Sato K, Horio E, Yoshimura H, Arima Y, Kojima S, Tayama S, Nakamura S, Sugiyama S, Hibi K, Kimura K, Umemura S, Ogawa H
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Related Report
-
-
[Presentation] Impaired Peripheral Endothelial Function as Assessed by Digital Reactive Hyperemia Peripheral Arterial Tonometry and Risk of In-Stent Restenosis.2013
Author(s)
Komura N, Tsujita K, Yamanaga K, Kaikita K, Hokimoto S, Iwashita S, Miyazaki T, Akasaka T, Sato K, Horio E, Yoshimura H, Arima Y, Kojima S, Tayama S, Nakamura S, Sugiyama S, Hibi K, Kimura K, Umemura S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Related Report
-
-
[Presentation] Single-Wire Pressure and Flow Velocity Measurement to Quantify Microvascular Dysfunction in Patients With Coronary Vasospastic Angina.2013
Author(s)
Yamanaga K, Tsujita K, Komura N, Kaikita K, Hokimoto S, Miyazaki T, Saito M, Akasaka T, Sato K, Horio E, Yoshimura H, Arima Y, Kojima S, Tayama S, Nakamura S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Related Report
-
[Presentation] Impact of Acetylcholine-provoked Diffuse Coronary Spasm on Clinical Features and Long-term Prognosis of Patients With Coronary Spasm.2013
Author(s)
Sato K, Kaikita K, Yoshimura H, Nakayama N, Horio E, Ohba K, Tsujita K, Tayama S, Hokimoto S, Matsui K, Sugiyama S, Yamabe H, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Related Report
-
[Presentation] Association between Abnormal Glucose Metabolism and Coronary Hyper-perfusion in Normal Coronary Patients Without Ischemic Heart Disease.2013
Author(s)
Fujisue K, Ohba K, Sugiyama S, Matsubara J, Nozaki T, Kurokawa H, Maeda H, Sumida H, Nagayoshi Y, Sakamoto K, Yamamoto E, Tsujita K, Hokimoto S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Related Report
-
[Presentation] Acetylcholine-Provoked Myocardial Lactate Production is Frequently Observed in Non-smoking Female Patients With Multivessel Coronary Spasm.2013
Author(s)
Kaikita K, Sato K, Nakayama N, Horio E, Yoshimura H, Tsujita K, Kojima S, Tayama S, Hokimoto S, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
Related Report
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[Presentation] Impact of Balloon Pulmonary Angioplasty on Chronic Thromboembolic Pulmonary Hypertension Complicated With Homocystinuria.2013
Author(s)
Katayama T, Ogawa S, Kaikita K, Tsukamoto M, Yamamoto E, Yamamuro M, Tanaka T, Tsujita K, Kojima S, Tayama S, Hokimoto S, Yamabe H, Indo Y, Endo F, Matsubara H, Ogawa H.
Organizer
86th American Heart Association Scientific Sessions
Place of Presentation
Dallas, TX, USA
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Author(s)
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Organizer
85th American Heart Association Scientific Sessions
Place of Presentation
Los Angeles, CA, USA
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[Presentation] Clinical and Morphological Presentations of Acute Coronary Syndrome without Coronary Plaque Rupture - An Intravascular Ultrasound Study -2012
Author(s)
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85th American Heart Association Scientific Sessions
Place of Presentation
Los Angeles, CA, USA
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[Presentation] Coronary Microvascular Dysfunction and Wall Stress Correlate with Cardiac Troponin T Release Measured by a Highly Sensitive Assay in Patients with Nonischemic Heart Failure2012
Author(s)
Takashio S, Yamamuro M, Izumiya Y, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H
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85th American Heart Association Scientific Sessions
Place of Presentation
Los Angeles, CA, USA
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Author(s)
Takaoka N, Tsujita K, Kaikita K, Hokimoto S, Mizobe M, Nagano M, Nakayama N, Horio E, Sato K, Yoshimura H, Kojima S, Tayama S, Sugiyama S, Nakamura S, Ogawa H.
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85th American Heart Association Scientific Sessions
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Horio E, Kaikita K, Miyata K, Kadomatsu T, Tazume H, Zhe1 T, Tsujita K, Tayama S, Hokimoto S, Sugiyama S, Takeya M, Ogawa H, Oike Y
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85th American Heart Association Scientific Sessions
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[Presentation] Clinical and Morphological Presentations of Acute Coronary Syndrome without Coronary Plaque Rupture - An Intravascular Ultrasound Study -2012
Author(s)
Tsujita K, Takaoka N, Kaikita K, Hokimoto S, Tayama S, Mizobe M, Sato K, Horio E, Nakayama N, Yoshimura H, Nagano M, Kojima S, Sugiyama S, Nakamura S, Ogawa H
Organizer
85th American Heart Association Scientific Sessions
Place of Presentation
Los Angeles, CA, アメリカ合衆国
Related Report
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[Presentation] Comprehensive Analysis of Intravascular Ultrasonic and Angiographic Morphology of Culprit Lesions Between ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Acute Coronary Syndrome.2012
Author(s)
Takaoka N, Tsujita K, Kaikita K, Hokimoto S, Mizobe M, Nagano M, Nakayama N, Horio E, Sato K, Yoshimura H, Kojima S, Tayama S, Sugiyama S, Nakamura S, Ogawa H
Organizer
85th American Heart Association Scientific Sessions
Place of Presentation
Los Angeles, CA, アメリカ合衆国
Related Report
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