The investigation of mechanism of salt-sensitive hypertension in animal models and cardiac diastolic heart failure in hypertensive patients
| Project/Area Number |
24790770
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 循環器学 / 血管内皮機能 / 血管内皮機能障害 / 慢性腎臓病 / 心拡張不全 / 高血圧 / 食塩感受性 / 一酸化窒素合成酵素 |
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| Research Abstract |
In the present study, we demonstrated the crucial role of eNOS uncoupling-induced vascular endothelial dysfunction in chronic kidney disease (CKD) and salt-sensitive hypertension using Dahl salt-sensitive hypertensive (DS) rats and eNOS knockout mice. Furthermore, in clinical study, we found that peripheral endothelial dysfunction, assessed by digital peripheral arterial tonometry, was significantly impaired in human cardiac diastolic heart failure (DHF) patients. Furthermore, blood BH4 levels tended to be decreased in DHF patients, indicating the involvement of eNOS uncoupling by BH4 downregulation in human DHF as well as DS rats.
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Report
(3 results)
Research Products
(55 results)
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[Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts prognosis of patients with heart failure with reduced ejection fraction.2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts.2014
Author(s)
Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
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Journal Title
Heart Vessels.
Volume: 29
Issue: 2
Pages: 231-237
DOI
Related Report
Peer Reviewed
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[Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction.2014
Author(s)
Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
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Journal Title
Can J Cardiol.
Volume: 30
Issue: 3
Pages: 338-344
DOI
Related Report
Peer Reviewed
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[Journal Article] Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure.2014
Author(s)
Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
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Journal Title
American Journal of Cardiology
Volume: 113
Issue: 10
Pages: 1697-1704
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endothelial function and cardiovascular events in chronic kidney disease.2014
Author(s)
Hirata Y, Sugiyama S, Yamamoto E, Matsuzawa Y, Akiyama E, Kusaka H, Fujisue K, Kurokawa H, Matsubara J, Sugamura K, Maeda H, Iwashita S, Jinnouchi H, Matsui K, Ogawa H.
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Journal Title
Int J Cardiol.
Volume: 173(3)
Issue: 3
Pages: 481-486
DOI
Related Report
Peer Reviewed
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[Journal Article] Tissue Inhibitor of Metalloproteinase-3 Knockout Mice Exhibit Enhanced Energy Expenditure through Thermogenesis2014
Author(s)
Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
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Journal Title
PLoS One
Volume: 9
Issue: 4
Pages: e94930-e94930
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Incremental prognostic significance of the elevated levels of Pentraxin 3 in patients with heart failure with normal left ventricular ejection.2014
Author(s)
Matsubara J, Sugiyama S, Nozaki T, Sugamura K, Konishi M, Ohba K, Matsuzawa Y, Akiyama E, Yamamoto E, Sakamoto K, Nagayoshi Y, Kaikita K, Sumida H, Kim-Mitsuyama S, Ogawa H.
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Journal Title
J Am Heart Assoc.
Volume: In Press
Related Report
Peer Reviewed
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[Journal Article] Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in uncontrolled diabetic patients with coronary artery disease.2013
Author(s)
Matsubara J, Sugiyama S, Akiyama E, Iwashita S, Kurokawa H, Ohba K, Maeda H, Fujisue K, Yamamoto E, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H.
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Journal Title
Circ J.
Volume: 77(5)
Pages: 1337-1344
Related Report
Peer Reviewed
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[Journal Article] Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure.2013
Author(s)
Takashio S, Yamamuro M, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
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Journal Title
J Am Coll Cardiol.
Volume: 62
Issue: 7
Pages: 632-640
DOI
Related Report
Peer Reviewed
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