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The investigation of mechanism of salt-sensitive hypertension in animal models and cardiac diastolic heart failure in hypertensive patients

Research Project

Project/Area Number 24790770
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionKumamoto University

Principal Investigator

YAMAMOTO Eiichiro  熊本大学, 医学部附属病院, 助教 (50573614)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords循環器学 / 血管内皮機能 / 血管内皮機能障害 / 慢性腎臓病 / 心拡張不全 / 高血圧 / 食塩感受性 / 一酸化窒素合成酵素
Research Abstract

In the present study, we demonstrated the crucial role of eNOS uncoupling-induced vascular endothelial dysfunction in chronic kidney disease (CKD) and salt-sensitive hypertension using Dahl salt-sensitive hypertensive (DS) rats and eNOS knockout mice. Furthermore, in clinical study, we found that peripheral endothelial dysfunction, assessed by digital peripheral arterial tonometry, was significantly impaired in human cardiac diastolic heart failure (DHF) patients. Furthermore, blood BH4 levels tended to be decreased in DHF patients, indicating the involvement of eNOS uncoupling by BH4 downregulation in human DHF as well as DS rats.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (55 results)

All 2014 2013 2012 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results,  Open Access: 2 results) Presentation (22 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Incremental prognostic significance of the elevated levels of Pentraxin 3 in patients with heart failure with normal left ventricular ejection2014

    • Author(s)
      Matsubara J., Yamamoto E., Ogawa H., et al
    • Journal Title

      J Am Heart Assoc

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts prognosis of patients with heart failure with reduced ejection fraction2014

    • Author(s)
      Hanatani S, Yamamoto E, Ogawa H., et al
    • Journal Title

      Circ J

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis2014

    • Author(s)
      Hanaoka Y., Yamamoto E., Ogawa H., et al
    • Journal Title

      PLoS One

      Volume: 9(4)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial function and cardiovascular events in chronic kidney disease.2014

    • Author(s)
      Hirata Y., Yamamoto E., Ogawa H., et al
    • Journal Title

      Int J Cardiol.

      Volume: 173(3) Pages: 481-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure.2014

    • Author(s)
      Takashio S., Yamamoto E., Ogawa H. et al
    • Journal Title

      Am J Cardiol

      Volume: 113(10) Pages: 1697-704

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction2014

    • Author(s)
      Izumiya Y., Yamamoto E., Ogawa H. et al
    • Journal Title

      Can J Cardiol

      Volume: 30(3) Pages: 338-44

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts2014

    • Author(s)
      Hanatani S, Yamamoto E, Ogawa H., et al
    • Journal Title

      Heart Vessels

      Volume: 29(2) Pages: 231-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts prognosis of patients with heart failure with reduced ejection fraction.2014

    • Author(s)
      Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
    • Journal Title

      Circ J.

      Volume: In Press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts.2014

    • Author(s)
      Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Journal Title

      Heart Vessels.

      Volume: 29 Issue: 2 Pages: 231-237

    • DOI

      10.1007/s00380-013-0337-y

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction.2014

    • Author(s)
      Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
    • Journal Title

      Can J Cardiol.

      Volume: 30 Issue: 3 Pages: 338-344

    • DOI

      10.1016/j.cjca.2013.12.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure.2014

    • Author(s)
      Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
    • Journal Title

      American Journal of Cardiology

      Volume: 113 Issue: 10 Pages: 1697-1704

    • DOI

      10.1016/j.amjcard.2014.02.029

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial function and cardiovascular events in chronic kidney disease.2014

    • Author(s)
      Hirata Y, Sugiyama S, Yamamoto E, Matsuzawa Y, Akiyama E, Kusaka H, Fujisue K, Kurokawa H, Matsubara J, Sugamura K, Maeda H, Iwashita S, Jinnouchi H, Matsui K, Ogawa H.
    • Journal Title

      Int J Cardiol.

      Volume: 173(3) Issue: 3 Pages: 481-486

    • DOI

      10.1016/j.ijcard.2014.03.085

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue Inhibitor of Metalloproteinase-3 Knockout Mice Exhibit Enhanced Energy Expenditure through Thermogenesis2014

    • Author(s)
      Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: e94930-e94930

    • DOI

      10.1371/journal.pone.0094930

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incremental prognostic significance of the elevated levels of Pentraxin 3 in patients with heart failure with normal left ventricular ejection.2014

    • Author(s)
      Matsubara J, Sugiyama S, Nozaki T, Sugamura K, Konishi M, Ohba K, Matsuzawa Y, Akiyama E, Yamamoto E, Sakamoto K, Nagayoshi Y, Kaikita K, Sumida H, Kim-Mitsuyama S, Ogawa H.
    • Journal Title

      J Am Heart Assoc.

      Volume: In Press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronary Microvascular Dysfunction and Diastolic Load Correlate with Cardiac Troponin T Release Measured by a Highly Sensitive Assay in Patients with Nonischemic Heart Failure2013

    • Author(s)
      Takashio S, Yamamoto E, Ogawa H., et al
    • Journal Title

      J Am Coll Cardiol

      Volume: 62(7) Pages: 632-640

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in uncontrolled diabetic patients with coronary artery disease2013

    • Author(s)
      Matsubara J., Yamamoto E., Ogawa H., et al
    • Journal Title

      Circ J.

      Volume: 77(5) Pages: 1337-1344

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in uncontrolled diabetic patients with coronary artery disease.2013

    • Author(s)
      Matsubara J, Sugiyama S, Akiyama E, Iwashita S, Kurokawa H, Ohba K, Maeda H, Fujisue K, Yamamoto E, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H.
    • Journal Title

      Circ J.

      Volume: 77(5) Pages: 1337-1344

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure.2013

    • Author(s)
      Takashio S, Yamamuro M, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 62 Issue: 7 Pages: 632-640

    • DOI

      10.1016/j.jacc.2013.03.065

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in uncontrolled diabetic patients with coronary artery disease.2013

    • Author(s)
      松原 純一、山本 英一郎、 他
    • Journal Title

      Circ J.

      Volume: In Press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coronary Microvascular Dysfunction and Diastolic Load Correlate with Cardiac Troponin T Release Measured by a Highly Sensitive Assay in Patients with Nonischemic Heart Failure2013

    • Author(s)
      高潮 征爾、山本 英一郎、 他
    • Journal Title

      J Am Coll Cardiol.

      Volume: In Press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease2012

    • Author(s)
      Ohba K., Yamamoto E., Ogawa H., et al
    • Journal Title

      J Am Heart Assoc

      Volume: 1(5)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium channel blockers, more than diuretics, enhance vascular protective effects of angiotensin receptor blockers in salt-loaded hypertensive rats2012

    • Author(s)
      Yamamoto E., Ogawa H., Kim-Mitsuyama S., et al
    • Journal Title

      PLoS One

      Volume: 7(6)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multidisciplinary mechanical supports improve outcome in a shock patient with cardiac amyloidosis : a case report2012

    • Author(s)
      Onoue Y., Yamamoto E., Ogawa H., et al
    • Journal Title

      Intern Med

      Volume: 51(10) Pages: 1215-9

    • NAID

      130002062458

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amlodipine enhances amelioration of vascular insulin resistance, oxidative stress, and metabolic disorders by candesartan in metabolic syndrome rat.2012

    • Author(s)
      Sueta D., Yamamoto E., Kim-Mitsuyama S. et al
    • Journal Title

      Am J Hypertens

      Volume: 25(6) Pages: 704-710

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel mechanism of angiotensin II-induced cardiac injury by in hypertensive rats: the critical role of ASK1 and VEGF2012

    • Author(s)
      名幸 久仁、山本 英一郎、 他
    • Journal Title

      Hypertens Res.

      Volume: Vol.35(2) Pages: 194-200

    • NAID

      10030643734

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic Variants at the 9p21 Locus Contribute to Atherosclerosis through Modulation of ANRIL and CDKN2A/B2012

    • Author(s)
      Congrains A., Yamamoto E., et al.
    • Journal Title

      Atherosclerosis.

      Volume: Vol. 220(2) Pages: 449-455

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amlodipine enhances amelioration of vascular insulin resistance, oxidative stress, and metabolic disorders by candesartan in metabolic syndrome rats.2012

    • Author(s)
      末田 大輔、山本 英一郎、 他
    • Journal Title

      Am J Hypertens.

      Volume: Vol.25(6) Pages: 704-710

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multidisciplinary mechanical supports improve outcome in a shock patient with cardiac amyloidosis: a case report.2012

    • Author(s)
      尾上 善郎、山本 英一郎、 他
    • Journal Title

      Intern Med.

      Volume: Vol.51(10) Pages: 1215-1219

    • NAID

      130002062458

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Calcium channel blockers, more than diuretics, enhance vascular protective effects of angiotensin receptor blockers in salt-loaded hypertensive rats.2012

    • Author(s)
      山本 英一郎、 他
    • Journal Title

      PLoS One.

      Volume: Vol.7(6)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease.2012

    • Author(s)
      大庭 圭介、山本 英一郎、 他
    • Journal Title

      J Am Heart Assoc.

      Volume: Vol.1(5)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 内皮型一酸化窒素合成酵素機能異常の心拡張不全病態での役割の臨床的検討2014

    • Author(s)
      山本英一郎、平田快紘、小川久雄
    • Organizer
      第14回日本NO学会学術集会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀県)
    • Year and Date
      2014-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] The Clinical Usefulness of Digital Peripheral Arterial Tonometry for Identifying Coronary Artery Disease in Hypertensive Patients2014

    • Author(s)
      山本英一郎、杉山正悟、小川久雄
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2014-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Cardiac Th1/Th2 Cytokine Imbalance was Closely Associated with the Transition from Left Ventricular Hypertrophy to Diastolic Heart Failure2014

    • Author(s)
      山本英一郎、日下裕章、小川久雄
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2014-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢発症急性冠症候群の臨床背景および式人病変の血管内超音波所見の検討2014

    • Author(s)
      山本英一郎、辻田賢一、小川久雄
    • Organizer
      第24回日本老年医学会九州地方会
    • Place of Presentation
      産業医科大学(福岡県)
    • Year and Date
      2014-03-08
    • Related Report
      2013 Final Research Report
  • [Presentation] AT1 Receptor Blockade Reverses not only Vascular Endothelial Dysfunction but also Cardiac Diastolic Dysfunction in Hypertensive Patients - ORION Study -2014

    • Author(s)
      山本 英一郎
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Clinical Usefulness of Digital Peripheral Arterial Tonometry2014

    • Author(s)
      山本 英一郎
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 内皮型一酸化窒素合成酵素(eNOS)機能異常の心拡張不全病態での役割の臨床的検討2014

    • Author(s)
      山本 英一郎
    • Organizer
      第14回日本NO学会学術集会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Clinical Usefulness of Digital Peripheral Arterial Tonometry for Identifying Coronary Artery Disease in Hypertensive Patients2013

    • Author(s)
      山本英一郎、松澤泰志、小川久雄
    • Organizer
      第86回米国心臓協会学術集会
    • Place of Presentation
      アメリカ合衆国ダラス市
    • Year and Date
      2013-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] アンジオテンシン受容体拮抗薬(ARB) : オルメサルタンは高血圧患者における血管内皮機能と拡張不全心不全を改善する2013

    • Author(s)
      山本英一郎、大庭圭介、小川久雄
    • Organizer
      第61回日本心臓病学会学術集会
    • Place of Presentation
      ホテル日航熊本(熊本県)
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] DES時代の降圧療法について-日本人でのエビデンスを中心に-2013

    • Author(s)
      山本英一郎、小川久雄
    • Organizer
      第22回日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Year and Date
      2013-07-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい線維化マーカーである Galectin-3の左室収縮保持性心不全における役割についての臨床的検討2013

    • Author(s)
      山本英一郎、日下裕章、小川久雄
    • Organizer
      第2回臨床高血圧フォーラム
    • Place of Presentation
      JPタワーホール(東京都)
    • Year and Date
      2013-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] AT1 Receptor Blockade Reverses not only Vascular Endothelial Dysfunction but also Cardiac Diastolic Dysfunction in Hypertensive Patients -ORION Study-2013

    • Author(s)
      山本英一郎、杉山正悟、小川久雄
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい線維化マーカーであるGalectin-3の左室収縮保持性心不全における役割についての臨床的検討2013

    • Author(s)
      山本 英一郎
    • Organizer
      第2回臨床高血圧フォーラム
    • Place of Presentation
      JPタワーホール(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DES時代の降圧療法について2013

    • Author(s)
      山本 英一郎
    • Organizer
      第22回 日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アンジオテンシン受容体拮抗薬(ARB):オルメサルタンは高血圧患者における血管内皮機能と拡張不全心不全を改善する2013

    • Author(s)
      山本 英一郎
    • Organizer
      第61回日本心臓病学会
    • Place of Presentation
      ホテル日航熊本(熊本県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Clinical Usefulness of Digital Peripheral Arterial Tonometry2013

    • Author(s)
      山本 英一郎
    • Organizer
      American Heart Association 2014
    • Place of Presentation
      Dallas, TX, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Clinical Usefulness of Digital Peripheral Arterial Tonometry for Identifying Coronary Artery Disease in Hypertensive Patients2013

    • Author(s)
      山本 英一郎
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] AT1 Receptor Blockade Reverses not only Vascular Endothelial Dysfunction but also Cardiac Diastolic Dysfunction in Hypertensive Patients2013

    • Author(s)
      山本 英一郎
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 新しい非侵襲的血管内皮機能測定による高血圧患者のリスク層別化について -Reactive Hyperemia Peripheral Arterial Tonometry(RH-PAT)を用いた検討-2012

    • Author(s)
      山本英一郎、杉山正悟、小川久雄
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル(愛知県)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい非侵襲的血管内皮機能測定による高血圧患者のリスク層別化2012

    • Author(s)
      山本 英一郎
    • Organizer
      第1回臨床高血圧フォーラム
    • Place of Presentation
      大阪府豊中市千里ライフサイエンスセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] 非侵襲的血管内皮機能測定による高血圧患者のリスク層別化について2012

    • Author(s)
      山本 英一郎
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      愛知県名古屋市ウェスティンナゴヤキャッスル
    • Related Report
      2012 Research-status Report
  • [Presentation] 高齢発症急性冠症候群の臨床背景および責任病変血管内超音波所見の検討

    • Author(s)
      山本 英一郎
    • Organizer
      第24回日本老年医学会九州地方会
    • Place of Presentation
      産業医科大学(福岡県)
    • Related Report
      2013 Annual Research Report
  • [Book] カレントテラピー2013

    • Author(s)
      山本英一郎、小川久雄
    • Publisher
      ライフメディコム
    • Related Report
      2012 Research-status Report
  • [Book] EBM 循環器疾患の治療 2012-20132012

    • Author(s)
      山本英一郎、光山勝慶、小川久雄
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] 血圧 19(10)2012

    • Author(s)
      山本英一郎、小川久雄
    • Publisher
      先端医学社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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