Analysis of physiological functions and translationl reserchs of Intrinsic Cardiac Adrenergic Cell in transplanted hearts

• Project/Area Number: 24790780
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Keio University
• Principal Investigator: TAMURA YUICHI 慶應義塾大学, 医学部, 特任助教 (00468498)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 分子心臓病態学 / 心臓移植 / 交感神経

Research Abstract

We identified the Intrinsic Cardiac Adrenergic Cell (ICA cell) are derived from neural crest by analyzing P0-Cre x Floxed-GFP transgenic mice. We found a promoting factor for the proliferation and differentiation into ICA cell as NGF. And we confirmed the contraction and heart rate of transplanted hearts were affected with the development of ICA cell.

Research Products

• [Presentation] Neural Crest-DerivedResident Cardiac Cells Contribute to the Restoration of Adrenergic Function ofTransplanted Heart in Rodent (2013)
  • Author(s): 田村雄一
  • Organizer: 第77回日本循環器学会学術集会(JCS2013)
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-15
• [Presentation] Neural crest-derived intrinsic cardiac adrenergic cells contribute to the restoration of adrenergic function of transplanted heart in rodent (2013)
  • Author(s): 田村雄一
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜
• [Presentation] Neural Crest-DerivedResident Cardiac Cells Contribute to the Restoration of Adrenergic Function ofTransplanted Heart in Rodent (2012)
  • Author(s): 田村雄一
  • Organizer: 米国心臓病学会議(AHA2012)
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2012-11-06
• [Presentation] Neural crest-derived intrinsic cardiac adrenergic cells contribute to the restoration of adrenergic function of transplanted heart in rodent (2012)
  • Author(s): 田村雄一
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: LosAngels, USA