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The functional role of autophagy in smooth muscle cell.

Research Project

Project/Area Number 24790782
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionJuntendo University

Principal Investigator

MITA Tomoya  順天堂大学, 医学部, 准教授 (90532557)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsオートファジー / 血管平滑筋細胞 / 動脈硬化 / 該当なし
Outline of Final Research Achievements

We investigated the role of autophagy in vascular smooth muscle cells (SMCs) on atherosclerosis. The apolipoprotein E-deficient mice, Atg7f/f and SM22α-Cre mice bred with each other to generate mice with SMCs specific Atg7 deficiency (ATG7-SMCs KO) and littermate control (control). For atherosclerosis study, 10-week-old male mice were placed on a Western diet containing 1.25% cholesterol for 14 weeks. Plaque sizes in abdominal aortic areas of ATG7-SMCs KO apolipoprotein E-deficient mice exceptionally expanded compared to control apolipoprotein E-deficient mice. Hydrogen peroxide induced apoptosis related signals were significantly enhanced in primary culture SMC isolated from ATG7-SMCs KO apolipoprotein E-deficient mice compared to those from control apolipoprotein E-deficient mice. Our data suggest that SMC autophagy play a protective role on atherosclerosis through inhibiting SMC cell death.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Anagliptin, a DPP-4 Inhibitor, Suppresses Proliferation of Vascular Smooth Muscles and Monocyte Inflammatory Reaction and Attenuates Atherosclerosis in Male apo E-Deficient Mice.2013

    • Author(s)
      Ervinna N, Mita T, Yasunari E, Azuma K, Tanaka R, Fujimura S, Sukmawati D, Nomiyama T, Kanazawa A, Kawamori R, Fujitani Y, Watada H
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 3 Pages: 1260-1270

    • DOI

      10.1210/en.2012-1855

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] インクレチン関連薬の抗動脈硬化作用2012

    • Author(s)
      三田 智也
    • Organizer
      日本糖尿病合併症学会
    • Place of Presentation
      アクロス福岡
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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